{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:39:31Z","timestamp":1791009571285,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T00:00:00Z","timestamp":1265155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We conducted a masked, crossover, therapeutic trial of gabapentin (1,200mg\/day) versus memantine (40mg\/day) for acquired nystagmus in 10 patients (aged 28\u201361 years; 7 female; 3 multiple sclerosis [MS]; 6 post\u2010stroke; 1 post\u2010traumatic). Nystagmus was pendular in 6 patients (4 oculopalatal tremor; 2 MS) and jerk upbeat, hemi\u2010seesaw, torsional, or upbeat\u2010diagonal in each of the others. For the group, both drugs reduced median eye speed (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), gabapentin by 32.8% and memantine by 27.8%, and improved visual acuity (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Each patient improved with 1 or both drugs. Side effects included unsteadiness with gabapentin and lethargy with memantine. Both drugs should be considered as treatment for acquired forms of nystagmus. ANN NEUROL 2010;67:676\u2013680\n                  <\/jats:p>","DOI":"10.1002\/ana.21991","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T10:04:48Z","timestamp":1265191488000},"page":"676-680","source":"Crossref","is-referenced-by-count":91,"title":["Crossover trial of gabapentin and memantine as treatment for acquired nystagmus"],"prefix":"10.1002","volume":"67","author":[{"given":"Matthew J.","family":"Thurtell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand C.","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice C.","family":"Leone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Tomsak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory S.","family":"Kosmorsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Stahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. John","family":"Leigh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,4,26]]},"reference":[{"key":"e_1_2_7_2_2","volume-title":"The neurology of eye movements","author":"Leigh RJ","year":"2006"},{"key":"e_1_2_7_3_2","article-title":"Therapy for nystagmus and its visual consequences","author":"Thurtell MJ","journal-title":"J Neuroophthalmol"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410620"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007728"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.71.1.107"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.086322"},{"key":"e_1_2_7_8_2","article-title":"Acquired pendular nystagmus in multiple sclerosis: an examiner\u2010blind cross\u2010over treatment study of memantine and gabapentin","author":"Starck M","journal-title":"J Neurol"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21065"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.09.025"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3458.2003.tb00254.x"},{"key":"e_1_2_7_12_2","article-title":"Oculopalatal tremor explained by model with inferior olivary hypertrophy and cerebellar plasticity","author":"Shaikh AG","journal-title":"Brain"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.11.1737"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-200109000-00005"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.54.7.627"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000342388.73185.80"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00228958"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(99)00142-X"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.21991","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.21991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T12:57:31Z","timestamp":1697461051000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.21991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,26]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.1002\/ana.21991"],"URL":"https:\/\/doi.org\/10.1002\/ana.21991","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.3792956.3525054","asserted-by":"object"}]},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,26]]}}}