{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:14:55Z","timestamp":1791357295824,"version":"4.3.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,3,23]],"date-time":"2010-03-23T00:00:00Z","timestamp":1269302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the possible efficacy of amantadine in the control of pathological gambling (PG) associated with Parkinson disease (PD), 17 PD patients with PG were randomly selected for a double\u2010blind crossover study with amantadine 200mg\/day versus placebo and an open follow\u2010up. Assessments included PG\u2010specific scales (Yale\u2010Brown Obsessive\u2010Compulsive Scale for PG, Gambling\u2010Symptom Assessment Scale, South Oaks Gambling Screen) and assessment of expenditures and time spent gambling. Amantadine abolished or reduced PG in all treated patients, as confirmed by scale score and daily expenditure reduction. Amantadine might be useful to treat PG. The effect of amantadine, acting as an antiglutamatergic agent, also opens new insights into the pathogenesis of PG. ANN NEUROL 2010<\/jats:p>","DOI":"10.1002\/ana.22029","type":"journal-article","created":{"date-parts":[[2010,3,23]],"date-time":"2010-03-23T19:29:46Z","timestamp":1269372586000},"page":"400-404","source":"Crossref","is-referenced-by-count":167,"title":["Pathological gambling in Parkinson disease is reduced by amantadine"],"prefix":"10.1002","volume":"68","author":[{"given":"Astrid","family":"Thomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bonanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Gambi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Di Iorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Onofrj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,30]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e32833109a0"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000137528.23126.41"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.2.299-b"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70225-X"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2515"},{"key":"e_1_2_7_7_2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/WNF.0b013e3181634ea6","article-title":"Dopamine dysregulation syndrome and levodopa\u2010induced dyskinesias in Parkinson disease: common consequences of anomalous forms of neural plasticity","volume":"32","author":"Linazasoro G","year":"2009","journal-title":"Clin Neuropharmacol"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02938408"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-199706000-00003"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70214-X"},{"issue":"4","key":"e_1_2_7_11_2","first-page":"S13","article-title":"Management of Parkinson's disease: an evidence\u2010based review. 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