{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:43:59Z","timestamp":1791859439585,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,8,31]],"date-time":"2010-08-31T00:00:00Z","timestamp":1283212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Although postoperative cognitive dysfunction (POCD) often complicates recovery from major surgery, the pathogenic mechanisms remain unknown. We explored whether systemic inflammation, in response to surgical trauma, triggers hippocampal inflammation and subsequent memory impairment, in a mouse model of orthopedic surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      C57BL\/6J, knock out (lacking interleukin [IL]\u20101 receptor, IL\u20101R\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      ) and wild type mice underwent surgery of the tibia under general anesthesia. Separate cohorts of animals were tested for memory function with fear conditioning tests, or euthanized at different times to assess levels of systemic and hippocampal cytokines and microglial activation; the effects of interventions, designed to interrupt inflammation (specifically and nonspecifically), were also assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Surgery caused hippocampal\u2010dependent memory impairment that was associated with increased plasma cytokines, as well as reactive microgliosis and IL\u20101\u03b2 transcription and expression in the hippocampus. Nonspecific attenuation of innate immunity with minocycline prevented surgery\u2010induced changes. Functional inhibition of IL\u20101\u03b2, both in mice pretreated with IL\u20101 receptor antagonist and in IL\u20101R\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice, mitigated the neuroinflammatory effects of surgery and memory dysfunction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation:<\/jats:title>\n                    <jats:p>A peripheral surgery\u2010induced innate immune response triggers an IL\u20101\u03b2\u2010mediated inflammatory process in the hippocampus that underlies memory impairment. This may represent a viable target to interrupt the pathogenesis of postoperative cognitive dysfunction. ANN NEUROL 2010;68:360\u2013368<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.22082","type":"journal-article","created":{"date-parts":[[2010,9,11]],"date-time":"2010-09-11T01:31:52Z","timestamp":1284168712000},"page":"360-368","source":"Crossref","is-referenced-by-count":661,"title":["Role of interleukin\u20101\u03b2 in postoperative cognitive dysfunction"],"prefix":"10.1002","volume":"68","author":[{"given":"Mario","family":"Cibelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Rei","family":"Fidalgo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niccol\u00f2","family":"Terrando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Monaco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Feldmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Takata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isobel J.","family":"Lever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagdeep","family":"Nanchahal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Fanselow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervyn","family":"Maze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,31]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)05270-3"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji137"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291798007740"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.07.040"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07382-0"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6896(03)00005-3"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200206000-00014"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200703000-00023"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000052712.67573.12"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.6.2095.bloodjournal8762095"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2007.09.004"},{"key":"e_1_2_7_13_2","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.4049\/jimmunol.159.5.2452","article-title":"Absence of IL\u20101 signaling and reduced inflammatory response in IL\u20101 type I receptor\u2010deficient mice","volume":"159","author":"Labow M","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20649"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)12252-4"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-06-02239.1998"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2007.04.013"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03001163"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-5-15"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.119.5.1396"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2008.06.006"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-21-09570.1999"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2132313100"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4695(199605)30:1<123::AID-NEU11>3.0.CO;2-N"},{"key":"e_1_2_7_25_2","first-page":"1273","article-title":"Comparison of the effects of frontal cortical and thalamic lesions on measures of olfactory learning and memory in the rat","volume":"111","author":"Koger SM","year":"1997","journal-title":"Behav Neurosci"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1006\/brbi.1998.0524"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611907200"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-008-0324-y"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.251341998"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4371-06.2007"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0023-9690(82)90021-2"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aem087"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:MEBR.0000043984.73063.d8"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04165.x"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002226200"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(02)00043-8"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-3776fje"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2005.05.012"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/1043-4666(92)90036-Q"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.09-09-03040.1989"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2005.05.024"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.02.001"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3376-06.2006"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200703000-00007"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2008.06.004"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-25-08692.2003"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/35068566"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.22082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.22082","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.22082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T01:58:09Z","timestamp":1697421489000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.22082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,31]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["10.1002\/ana.22082"],"URL":"https:\/\/doi.org\/10.1002\/ana.22082","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,31]]}}}