{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:46:10Z","timestamp":1789382770862,"version":"build-2803163510"},"reference-count":81,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,3,9]],"date-time":"2011-03-09T00:00:00Z","timestamp":1299628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Cerebral aneurysms can cause substantial morbidity and mortality, specifically if they rupture, leading to nontraumatic subarachnoid hemorrhage (SAH). This meta\u2010analysis summarizes evidence about the accuracy of noninvasive computed tomographic (CT) angiography for diagnosing intracranial aneurysms in symptomatic patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four databases including PubMed were searched without language restrictions from January 1995 to February 2010. Two independent reviewers selected and extracted 45 studies that compared CT angiography with digital subtraction angiography (DSA) and\/or intraoperative findings in patients suspected of having cerebral aneurysms. Data from eligible studies were used to reconstruct 2 \u00d7 2 contingency tables on a per\u2010patient basis in at least 5 diseased and 5 nondiseased patients, with additional data on a per\u2010aneurysm basis when available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 45 included studies generally were of high methodological quality. Among the 3,643 patients included, about 86% had nontraumatic SAH, and 77% had cerebral aneurysms. Overall, CT angiography had a pooled sensitivity of 97.2% (95% confidence interval, 95.8\u201398.2%) for detecting and specificity of 97.9% (95.7\u201399.0%) for ruling out cerebral aneurysms on a per\u2010patient basis. On a per\u2010aneurysm basis, the pooled sensitivity was 95.0% (93.2\u201396.4%), and the specificity 96.2% (92.9\u201398.0%). The diagnostic accuracy of CT angiography with 16\u2010 or 64\u2010row multidetector CT was significantly higher than that of single\u2010detector CT, especially in detecting small aneurysms of \u22644mm in diameter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>CT angiography has a high accuracy in diagnosing cerebral aneurysms, specifically when using modern multidetector CT. In the future, CT angiography may increasingly supplement or selectively replace DSA in patients suspected of having a cerebral aneurysm. ANN NEUROL 2011<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.22270","type":"journal-article","created":{"date-parts":[[2011,3,9]],"date-time":"2011-03-09T13:53:08Z","timestamp":1299678788000},"page":"646-654","source":"Crossref","is-referenced-by-count":114,"title":["Diagnosing cerebral aneurysms by computed tomographic angiography: Meta\u2010analysis"],"prefix":"10.1002","volume":"69","author":[{"given":"Jan","family":"Menke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Kallenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,9]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052760"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60153-6"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.191395"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10140-009-0824-8"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-8467(78)80006-7"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1979.51.3.0352"},{"key":"e_1_2_8_8_2","first-page":"361","volume":"217","author":"White PM","year":"2000","journal-title":"Can noninvasive imaging accurately depict intracranial aneurysms? A systematic review. Radiology"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000047895.82857.EB"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000080060.97293.EE"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00136"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-3-25"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.01.016"},{"key":"e_1_2_8_15_2","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3414\/ME09-01-0001","article-title":"Bivariate random\u2010effects meta\u2010analysis of sensitivity and specificity with SAS PROC GLIMMIX","volume":"49","author":"Menke J.","year":"2010","journal-title":"Methods Inf Med"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-009-1403-9"},{"key":"e_1_2_8_17_2","first-page":"31","volume":"6","author":"Zamora J","year":"2006","journal-title":"et al. Meta\u2010DiSc: a software for meta\u2010analysis of test accuracy data. BMC Med Res Methodol"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-12-200812160-00008"},{"key":"e_1_2_8_20_2","first-page":"1559","volume":"21","author":"Thompson SG","year":"2002","journal-title":"How should meta\u2010regression analyses be undertaken and interpreted? Stat Med"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(03)00177-X"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.165.2.7618571"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.165.6.7484596"},{"key":"e_1_2_8_24_2","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1080\/02841859709172412","article-title":"Cerebral CT angiography in the diagnosis of acute subarachnoid hemorrhage","volume":"38","author":"Lenhart M","year":"1997","journal-title":"Acta Radiol"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199709000-00003"},{"key":"e_1_2_8_26_2","first-page":"63","article-title":"Aneurysmanachweis bei Subarachnoidalblutung\u2014CT\u2010Angiographie versus digitale Subtraktionsangiographie","volume":"8","author":"Rohnert W","year":"1998","journal-title":"Aktuelle Radiol"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.208.2.9680571"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050712"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199912000-00008"},{"key":"e_1_2_8_30_2","first-page":"247","article-title":"Aneurismas cerebrales: estudio mediante TC\u2010helicoidal (angio\u2010TC) con reconstrucciones tridimensionales","volume":"41","author":"Montes JM","year":"1999","journal-title":"Radiologia"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.211.2.r99ma02497"},{"key":"e_1_2_8_32_2","first-page":"275","article-title":"Acute subarachnoid haemorrhage: detection of aneurysms of intracranial arteries by computed tomographic angiography","volume":"33","author":"Milosevic Z.","year":"1999","journal-title":"Radiol Oncol"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/197140090001300506"},{"key":"e_1_2_8_34_2","first-page":"43","article-title":"CTA in patients with acute subarachnoid haemorrhage","volume":"42","author":"Pedersen HK","year":"2001","journal-title":"A comparative study with selective, digital angiography and blinded, independent review. Acta Radiol"},{"key":"e_1_2_8_35_2","first-page":"140","article-title":"Galvos smegenu kompiuterines tomografijos angiografija ivykus subarachnoidinei hemoragijai","volume":"38","author":"Lukosevicius S","year":"2002","journal-title":"Medicina (Kaunas)"},{"key":"e_1_2_8_36_2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00330-002-1520-1","article-title":"The non\u2010invasive detection of intracranial aneurysms: are neuroradiologists any better than other observers","volume":"13","author":"White PM","year":"2003","journal-title":"Eur Radiol"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.98.4.0828"},{"key":"e_1_2_8_38_2","first-page":"1485","article-title":"Multi\u2010section CT angiography for detection of cerebral aneurysms","volume":"25","author":"Teksam M","year":"2004","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0720-048X(03)00173-6"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-003-1155-1"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000125325.22576.83"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2302021465"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2004.09.012"},{"key":"e_1_2_8_44_2","first-page":"867","article-title":"Evaluation of circle of Willis aneurysms with spiral computed tomographic angiography","volume":"30","author":"Pavcec Z","year":"2006","journal-title":"Coll Antropol"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0150-9861(06)77227-3"},{"key":"e_1_2_8_46_2","first-page":"103","article-title":"Angiografija kompjutoriziranom tomografijom u dijagnostici unutarlubanjskih aneurizmi","volume":"42","author":"Halaji A","year":"2006","journal-title":"Medicina (Rijeka)"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-006-0129-5"},{"key":"e_1_2_8_48_2","first-page":"60","article-title":"Detection and characterization of intracranial aneurysms with 16\u2010channel multidetector row CT angiography: a prospective comparison of volume\u2010rendered images and digital subtraction angiography","volume":"28","author":"Yoon DY","year":"2007","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0699"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2007.02.018"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2007.00160.x"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2007.07.006"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-007-0126-8"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2442060394"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0741"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0848"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1080\/02688690701713862"},{"key":"e_1_2_8_58_2","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1097\/00029330-200812020-00010","article-title":"Combined application of virtual imaging techniques and three\u2010dimensional computed tomographic angiography in diagnosing intracranial aneurysms","volume":"121","author":"Guo YW","year":"2008","journal-title":"Chin Med J"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10140-008-0727-0"},{"key":"e_1_2_8_60_2","first-page":"209","article-title":"Diagnostic accuracy of multi\u2010slice computed tomographic (MSCT) angiography in the detection of cerebral aneurysms","volume":"5","author":"Haghighatkhah HR","year":"2008","journal-title":"Iran J Radiol"},{"key":"e_1_2_8_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-009-1416-4"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2009.07.004"},{"key":"e_1_2_8_63_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2523081911"},{"key":"e_1_2_8_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2007.08.005"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-009-0508-x"},{"key":"e_1_2_8_66_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.08.2290"},{"key":"e_1_2_8_67_2","doi-asserted-by":"publisher","DOI":"10.1109\/42.819325"},{"key":"e_1_2_8_68_2","first-page":"280","volume-title":"Medical image analysis","author":"Dhawan AP","year":"2003"},{"key":"e_1_2_8_69_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-1-200301070-00012-w1"},{"key":"e_1_2_8_70_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-008-1171-y"},{"key":"e_1_2_8_71_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000317403.23713.92"},{"key":"e_1_2_8_72_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0964"},{"key":"e_1_2_8_73_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2463071392"},{"key":"e_1_2_8_74_2","first-page":"1199","article-title":"Comparison of three\u2010dimensional rotational angiography with digital subtraction angiography in the assessment of ruptured cerebral aneurysms","volume":"23","author":"Hochmuth A","year":"2002","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_8_75_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1444"},{"key":"e_1_2_8_76_2","doi-asserted-by":"publisher","DOI":"10.1118\/1.2198941"},{"key":"e_1_2_8_77_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-006-0156-y"},{"key":"e_1_2_8_78_2","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/54\/11\/006"},{"key":"e_1_2_8_79_2","first-page":"947","article-title":"Dynamic imaging of a model of intracranial saccular aneurysms using ultra\u2010high\u2010resolution flat\u2010panel volumetric computed tomography","volume":"111","author":"Mitha AP","year":"2009","journal-title":"Laboratory investigation. J Neurosurg"},{"key":"e_1_2_8_80_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-009-1688-8"},{"key":"e_1_2_8_81_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/27721218"},{"key":"e_1_2_8_82_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2501071809"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.22270","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.22270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T05:38:50Z","timestamp":1697434730000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.22270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,9]]},"references-count":81,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1002\/ana.22270"],"URL":"https:\/\/doi.org\/10.1002\/ana.22270","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,9]]}}}