{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:29:56Z","timestamp":1791116996569,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,8,5]],"date-time":"2011-08-05T00:00:00Z","timestamp":1312502400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>There is a growing need to identify cerebrospinal fluid (CSF) markers that can detect Alzheimer's disease (AD) pathology in cognitively normal individuals because it is in this population that disease\u2010modifying therapies may have the greatest chance of success. While AD pathology is estimated to begin \u223c10\u201315 years prior to the onset of cognitive decline, substantial neuronal loss is present by the time the earliest signs of cognitive impairment appear. Visinin\u2010like protein\u20101 (VILIP\u20101) has demonstrated potential utility as a marker of neuronal injury. Here we investigate CSF VILIP\u20101 and VILIP\u20101\/amyloid\u2010\u03b242 (A\u03b242) ratio as diagnostic and prognostic markers in early AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We assessed CSF levels of VILIP\u20101, tau, phosphorylated\u2010tau181 (p\u2010tau181), and A\u03b242 in cognitively normal controls (CNC) (n = 211), individuals with early symptomatic AD (n = 98), and individuals with other dementias (n = 19). Structural magnetic resonance imaging (n = 192) and amyloid imaging with Pittsburgh Compound\u2010B (n = 156) were obtained in subsets of this cohort. Among the CNC cohort, 164 individuals had follow\u2010up annual cognitive assessments for 2\u20133 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>CSF VILIP\u20101 levels differentiated individuals with AD from CNC and individuals with other dementias. CSF VILIP\u20101 levels correlated with CSF tau, p\u2010tau181, and brain volumes in AD. VILIP\u20101 and VILIP\u20101\/A\u03b242 predicted future cognitive impairment in CNC over the follow\u2010up period. Importantly, CSF VILIP\u20101\/A\u03b242 predicted future cognitive impairment at least as well as tau\/A\u03b242 and p\u2010tau181\/A\u03b242.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation:<\/jats:title><jats:p>These findings suggest that CSF VILIP\u20101 and VILIP\u20101\/A\u03b242 offer diagnostic utility for early AD, and can predict future cognitive impairment in cognitively normal individuals similarly to tau and tau\/A\u03b242, respectively. ANN NEUROL 2011;<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.22448","type":"journal-article","created":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T19:16:45Z","timestamp":1302203805000},"page":"274-285","source":"Crossref","is-referenced-by-count":144,"title":["Visinin\u2010like protein\u20101: Diagnostic and prognostic biomarker in Alzheimer disease"],"prefix":"10.1002","volume":"70","author":[{"given":"Rawan","family":"Tarawneh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"D'Angelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Macy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjie","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel J.","family":"Cairns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne 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