{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:56:14Z","timestamp":1791291374203,"version":"4.3.0"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,12,21]],"date-time":"2011-12-21T00:00:00Z","timestamp":1324425600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>Several studies have suggested an increased frequency of variants in the gene encoding angiogenin (<jats:italic>ANG<\/jats:italic>) in patients with amyotrophic lateral sclerosis (ALS). Interestingly, a few ALS patients carrying <jats:italic>ANG<\/jats:italic> variants also showed signs of Parkinson disease (PD). Furthermore, relatives of ALS patients have an increased risk to develop PD, and the prevalence of concomitant motor neuron disease in PD is higher than expected based on chance occurrence. We therefore investigated whether <jats:italic>ANG<\/jats:italic> variants could predispose to both ALS and PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We reviewed all previous studies on <jats:italic>ANG<\/jats:italic> in ALS and performed sequence experiments on additional samples, which allowed us to analyze data from 6,471 ALS patients and 7,668 controls from 15 centers (13 from Europe and 2 from the USA). We sequenced DNA samples from 3,146 PD patients from 6 centers (5 from Europe and 1 from the USA). Statistical analysis was performed using the variable threshold test, and the Mantel\u2010Haenszel procedure was used to estimate odds ratios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Analysis of sequence data from 17,258 individuals demonstrated a significantly higher frequency of <jats:italic>ANG<\/jats:italic> variants in both ALS and PD patients compared to control subjects (<jats:italic>p<\/jats:italic> = 9.3 \u00d7 10<jats:sup>\u22126<\/jats:sup> for ALS and <jats:italic>p<\/jats:italic> = 4.3 \u00d7 10<jats:sup>\u22125<\/jats:sup> for PD). The odds ratio for any <jats:italic>ANG<\/jats:italic> variant in patients versus controls was 9.2 for ALS and 6.7 for PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation:<\/jats:title><jats:p>The data from this multicenter study demonstrate that there is a strong association between PD, ALS, and <jats:italic>ANG<\/jats:italic> variants. <jats:italic>ANG<\/jats:italic> is a genetic link between ALS and PD. ANN NEUROL 2011;70:964\u2013973<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.22611","type":"journal-article","created":{"date-parts":[[2011,8,17]],"date-time":"2011-08-17T18:55:35Z","timestamp":1313607335000},"page":"964-973","source":"Crossref","is-referenced-by-count":185,"title":["Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"70","author":[{"given":"Michael A.","family":"van Es","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helenius J.","family":"Schelhaas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W. 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