{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:31:00Z","timestamp":1787729460735,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T00:00:00Z","timestamp":1330041600000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Little is known about the composition of middle cerebral artery (MCA) plaques and how they relate to clinical status. Using high\u2010resolution magnetic resonance imaging (HR\u2010MRI), we aimed to examine the occurrence of high signal on T1\u2010weighted fat\u2010suppressed images (HST1) of MCA plaques, which are highly suggestive of fresh or recent intraplaque hemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed the HR\u2010MRI and clinical\n                      <jats:bold>data<\/jats:bold>\n                      of 107 adult patients with high\u2010grade (&gt;70%) MCA stenosis. On HR\u2010MRI, HST1 within an MCA plaque was defined as an area with an intensity &gt;150% of the signal of adjacent muscles. The relationship between HST1 and clinical presentations was analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 109 stenotic MCAs (46 symptomatic and 63 asymptomatic) on 981 image slices were analyzed. HST1 was revealed on HR\u2010MRI in 11 vessels (10.1%, 9 symptomatic and 2 asymptomatic). The occurrence rate of HST1 between symptomatic and asymptomatic MCAs was significantly different (19.6% vs 3.2%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation:<\/jats:title>\n                    <jats:p>HST1 within MCA plaque on HR\u2010MRI is associated with ipsilateral stroke. Our results provide new insight into the vascular biology of MCA atherosclerosis. Ann Neurol 2012;71:195\u2013198<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.22626","type":"journal-article","created":{"date-parts":[[2011,9,12]],"date-time":"2011-09-12T12:38:51Z","timestamp":1315831131000},"page":"195-198","source":"Crossref","is-referenced-by-count":157,"title":["Middle cerebral artery intraplaque hemorrhage: Prevalence and Clinical Relevance"],"prefix":"10.1002","volume":"71","author":[{"given":"Wei\u2010Hai","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Xin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng\u2010Yu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Ying","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.505776"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.578229"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22354"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.06.035"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.528174"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000111525"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000342470.69739.b3"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000225074.47396.71"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-7071(01)00328-X"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.106.473066"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2009.00442.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2010.00499.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.10.019"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.579474"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000125856.25309.86"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.106.479139"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.127969"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000147287.23741.9A"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000178991.71605.18"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.192179"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.09.064"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.24.2666"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1966.00470080008002"},{"key":"e_1_2_6_25_2","first-page":"427","volume-title":"Stroke: 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