{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:58:05Z","timestamp":1790805485740,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,12,31]],"date-time":"2012-12-31T00:00:00Z","timestamp":1356912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a frequent autoimmune neuropathy with a heterogeneous clinical spectrum. Clinical and experimental evidence suggests that autoantibodies may be involved in its pathogenesis, but the target antigens are unknown. Axoglial junction proteins have been proposed as candidate antigens. We examined the reactivity of CIDP patients' sera against neuronal antigens and used immunoprecipitation for antigen unraveling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Primary cultures of hippocampal neurons were used to select patients' sera that showed robust reactivity with the cell surface of neurons. The identity of the antigens was established by immunoprecipitation and mass spectrometry, and subsequently confirmed with cell\u2010based assays, immunohistochemistry with teased rat sciatic nerve, and immunoabsorption experiments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four of 46 sera from patients with CIDP reacted strongly against hippocampal neurons (8.6%) and paranodal structures on peripheral nerve. Two patients' sera precipitated contactin\u20101 (CNTN1), and 1 precipitated both CNTN1 and contactin\u2010associated protein 1 (CASPR1). Reactivity against CNTN1 was confirmed in 2 cases, whereas the third reacted only when CNTN1 and CASPR1 were cotransfected. No other CIDP patient or any of the 104 controls with other neurological diseases tested positive. All 3 patients shared common clinical features, including advanced age, predominantly motor involvement, aggressive symptom onset, early axonal involvement, and poor response to intravenous immunoglobulin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Antibodies against the CNTN1\/CASPR1 complex occur in a subset of patients with CIDP who share common clinical features. The finding of this biomarker may help to explain the symptoms of these patients and the heterogeneous response to therapy in CIDP. ANN NEUROL 2013;73:370\u2013380<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.23794","type":"journal-article","created":{"date-parts":[[2012,10,30]],"date-time":"2012-10-30T14:56:10Z","timestamp":1351608970000},"page":"370-380","source":"Crossref","is-referenced-by-count":331,"title":["Antibodies to contactin\u20101 in chronic inflammatory demyelinating polyneuropathy"],"prefix":"10.1002","volume":"73","author":[{"given":"Luis","family":"Querol","sequence":"first","affiliation":[{"name":"Neuromuscular Diseases Unit Neurology Department Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f3noma de Barcelona Barcelona"},{"name":"Centro Investigaci\u00f3n Biom\u00e9dica en Red para Enfermedades Neurodegenerativas Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Nogales\u2010Gadea","sequence":"additional","affiliation":[{"name":"Neuromuscular Diseases Unit Neurology Department Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f3noma de Barcelona Barcelona"},{"name":"Centro Investigaci\u00f3n Biom\u00e9dica en Red para Enfermedades Neurodegenerativas Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricard","family":"Rojas\u2010Garcia","sequence":"additional","affiliation":[{"name":"Neuromuscular Diseases Unit Neurology Department Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f3noma de Barcelona Barcelona"},{"name":"Centro Investigaci\u00f3n Biom\u00e9dica en Red para Enfermedades Neurodegenerativas Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Martinez\u2010Hernandez","sequence":"additional","affiliation":[{"name":"Neuromuscular Diseases Unit Neurology Department Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f3noma de Barcelona Barcelona"},{"name":"Centro Investigaci\u00f3n Biom\u00e9dica en Red para Enfermedades Neurodegenerativas Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Diaz\u2010Manera","sequence":"additional","affiliation":[{"name":"Neuromuscular Diseases Unit Neurology Department Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f3noma de Barcelona Barcelona"},{"name":"Centro Investigaci\u00f3n Biom\u00e9dica en Red para Enfermedades Neurodegenerativas Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Su\u00e1rez\u2010Calvet","sequence":"additional","affiliation":[{"name":"Neuromuscular Diseases Unit Neurology Department Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f3noma de Barcelona Barcelona"},{"name":"Centro Investigaci\u00f3n Biom\u00e9dica en Red para Enfermedades Neurodegenerativas Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Navas","sequence":"additional","affiliation":[{"name":"Neuromuscular Diseases Unit Neurology Department Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f3noma de Barcelona Barcelona"},{"name":"Centro Investigaci\u00f3n Biom\u00e9dica en Red para Enfermedades Neurodegenerativas Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefa","family":"Araque","sequence":"additional","affiliation":[{"name":"Neuromuscular Diseases Unit Neurology Department Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f3noma de Barcelona Barcelona"},{"name":"Centro Investigaci\u00f3n Biom\u00e9dica en Red para Enfermedades Neurodegenerativas Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Gallardo","sequence":"additional","affiliation":[{"name":"Neuromuscular Diseases Unit Neurology Department Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f3noma de Barcelona Barcelona"},{"name":"Centro Investigaci\u00f3n Biom\u00e9dica en Red para Enfermedades Neurodegenerativas Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Isabel Illa","sequence":"additional","affiliation":[{"name":"Neuromuscular Diseases Unit Neurology Department Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f3noma de Barcelona Barcelona"},{"name":"Centro Investigaci\u00f3n Biom\u00e9dica en Red para Enfermedades Neurodegenerativas Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041347"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.12_suppl_6.S7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02930.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2011.00298.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1085-9489.2006.00061.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1980.00500590061010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200006)47:6<765::AID-ANA9>3.0.CO;2-8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807319106"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg030"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(93)90255-W"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(01)00307-1"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1129"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1085-9489.2005.0010207.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.106617"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.2.234"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.159798"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(99)00269-6"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2011.00323.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq372"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2012.00372.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014533"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bd1139"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00296-3"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00294-X"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181be2e96"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M809227200"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(91)90003-3"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70137-X"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.468"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1994.tb00288.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22297"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1743"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/400_2009_3"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.99"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182407982"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.23794","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.23794","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T10:19:30Z","timestamp":1700648370000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.23794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,31]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1002\/ana.23794"],"URL":"https:\/\/doi.org\/10.1002\/ana.23794","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718013260.793477339","asserted-by":"object"}]},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,31]]}}}