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Leveraging a genetically engineered mouse model of neurofibromatosis type 1 (NF1)\u2010associated optic glioma, we now demonstrate that stromal microglia express the CX3CR1 chemokine receptor, such that reduced CX3CR1 expression decreases optic nerve microglia. Moreover, genetic reduction of <jats:italic>Cx3cr1<\/jats:italic> expression in <jats:italic>Nf1<\/jats:italic> optic glioma mice delays optic glioma formation. Coupled with previous findings demonstrating that microglia maintain optic glioma growth, these new findings provide a strong preclinical rationale for the development of future stroma\u2010directed glioma therapies in children. 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