{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:15:58Z","timestamp":1790075758842,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T00:00:00Z","timestamp":1378252800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>Prevalence of neuropathic pain is high after major surgery. However, effective treatment for preventing neuropathic pain is lacking. Here we report that perisurgical treatment of neuroprotectin D1\/protectin D1 (NPD1\/PD1), derived from docosahexaenoic acid, prevents nerve injury\u2010induced mechanical allodynia and ongoing pain in mice. Intrathecal post\u2010treatment of NPD1\/PD1 also effectively reduces established neuropathic pain and produces no apparent signs of analgesic tolerance. Mechanistically, NPD1\/PD1 treatment blocks nerve injury\u2010induced long\u2010term potentiation, glial reaction, and inflammatory responses, and reverses synaptic plasticity in the spinal cord. Thus, NPD1\/PD1 and related mimetics might serve as a new class of analgesics for preventing and treating neuropathic pain. Ann Neurol 2013;74:490\u2013495<\/jats:p>","DOI":"10.1002\/ana.23928","type":"journal-article","created":{"date-parts":[[2013,5,18]],"date-time":"2013-05-18T08:07:04Z","timestamp":1368864424000},"page":"490-495","source":"Crossref","is-referenced-by-count":128,"title":["Neuroprotectin\/protectin D1 protects against neuropathic pain in mice after nerve trauma"],"prefix":"10.1002","volume":"74","author":[{"given":"Zhen\u2010Zhong","family":"Xu","sequence":"first","affiliation":[{"name":"Pain Signaling and Plasticity Laboratory, Department of Anesthesiology and Neurobiology Duke University Medical Center Durham NC"},{"name":"Department of Anesthesiology, Brigham and Women's Hospital Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing\u2010Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Pain Signaling and Plasticity Laboratory, Department of Anesthesiology and Neurobiology Duke University Medical Center Durham 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