{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:03:57Z","timestamp":1787321037093,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,5,2]],"date-time":"2014-05-02T00:00:00Z","timestamp":1398988800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Abnormal cortical excitability is evident in various movement disorders that compromise fine motor control. Here we tested whether skilled finger movements can be restored in musicians with focal hand dystonia through behavioral training assisted by transcranial direct current stimulation to the motor cortex of both hemispheres.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The bilateral motor cortices of 20 pianists (10 with focal dystonia, 10 healthy controls) were electrically stimulated noninvasively during bimanual mirrored finger movements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found improvement in the rhythmic accuracy of sequential finger movements with the affected hand during and after cathodal stimulation over the affected cortex and simultaneous anodal stimulation over the unaffected cortex. The improvement was retained 4 days after intervention. Neither a stimulation with the reversed montage of electrodes nor sham stimulation yielded any improvement. Furthermore, the amount of improvement was positively correlated with the severity of the symptoms. Bihemispheric stimulation without concurrent motor training failed to improve fine motor control, underlining the importance of combined retraining and stimulation for restoring the dystonic symptoms. For the healthy pianists, none of the stimulation protocols enhanced movement accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>These results suggest a therapeutic potential of behavioral training assisted by bihemispheric, noninvasive brain stimulation in restoring fine motor control in focal dystonia. ANN NEUROL 2014;75:700\u2013707<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.24151","type":"journal-article","created":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T04:33:20Z","timestamp":1396845200000},"page":"700-707","source":"Crossref","is-referenced-by-count":74,"title":["Surmounting retraining limits in Musicians' dystonia by transcranial stimulation"],"prefix":"10.1002","volume":"75","author":[{"given":"Shinichi","family":"Furuya","sequence":"first","affiliation":[{"name":"Institute for Music Physiology and Musicians' Medicine, Hanover University of Music, Drama, and Media  Hanover"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Nitsche","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology University Medical Center G\u00f6ttingen, Georg\u2010August\u2010University G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Paulus","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology University Medical Center G\u00f6ttingen, Georg\u2010August\u2010University G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckart","family":"Altenm\u00fcller","sequence":"additional","affiliation":[{"name":"Institute for Music Physiology and Musicians' Medicine, Hanover University of Music, Drama, and Media  Hanover"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.7.1005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.05.025"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.08.025"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3564-08.2008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh017"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh402"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20270"},{"key":"e_1_2_7_9_1","first-page":"247","article-title":"Differential activation in the primary motor cortex during individual digit movement in focal hand dystonia vs","volume":"30","author":"Kimberley TJ","year":"2012","journal-title":"healthy. 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