{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:33:46Z","timestamp":1784691226049,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,7,21]],"date-time":"2014-07-21T00:00:00Z","timestamp":1405900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>Tourette syndrome (TS) is a neurodevelopmental disorder with a complex genetic etiology. Through an international collaboration, we genotyped 42 single nucleotide polymorphisms (<jats:italic>p<\/jats:italic>\u2009&lt;\u200910<jats:sup>\u22123<\/jats:sup>) from the recent TS genomewide association study (GWAS) in 609 independent cases and 610 ancestry\u2010matched controls. Only rs2060546 on chromosome 12q22 (<jats:italic>p<\/jats:italic>\u2009=\u20093.3 \u00d7 10<jats:sup>\u22124<\/jats:sup>) remained significant after Bonferroni correction. Meta\u2010analysis with the original GWAS yielded the strongest association to date (<jats:italic>p<\/jats:italic>\u2009=\u20095.8 \u00d7 10<jats:sup>\u22127<\/jats:sup>). Although its functional significance is unclear, rs2060546 lies closest to <jats:italic>NTN4<\/jats:italic>, an axon guidance molecule expressed in developing striatum. Risk score analysis significantly predicted case\u2013control status (<jats:italic>p<\/jats:italic>\u2009=\u20090.042), suggesting that many of these variants are true TS risk alleles. Ann Neurol 2014;76:310\u2013315<\/jats:p>","DOI":"10.1002\/ana.24215","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T09:35:31Z","timestamp":1404984931000},"page":"310-315","source":"Crossref","is-referenced-by-count":60,"title":["Genetic association signal near <scp><i>NTN<\/i><\/scp><i>4<\/i> in <scp>T<\/scp>ourette syndrome"],"prefix":"10.1002","volume":"76","author":[{"given":"Peristera","family":"Paschou","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics Democritus University of Thrace Alexandroupoli Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Yu","sequence":"additional","affiliation":[{"name":"Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School Boston MA"},{"name":"Stanley Center for Psychiatric Research Broad Institute of Harvard and Massachusetts Institute of Technology Cambridge MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Gerber","sequence":"additional","affiliation":[{"name":"Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Evans","sequence":"additional","affiliation":[{"name":"Section of Genetic Medicine, Department of Medicine University of Chicago Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotis","family":"Tsetsos","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Democritus University of Thrace Alexandroupoli Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea K.","family":"Davis","sequence":"additional","affiliation":[{"name":"Section of Genetic Medicine, Department of Medicine University of Chicago Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iordanis","family":"Karagiannidis","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Democritus University of Thrace Alexandroupoli Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Chaponis","sequence":"additional","affiliation":[{"name":"Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Gamazon","sequence":"additional","affiliation":[{"name":"Section of Genetic Medicine, Department of Medicine University of Chicago Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Mueller\u2010Vahl","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Social Psychiatry, and Psychotherapy Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Stuhrmann","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Schloegelhofer","sequence":"additional","affiliation":[{"name":"Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Stamenkovic","sequence":"additional","affiliation":[{"name":"Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy Medical University of Vienna Vienna 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Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy L.","family":"Budman","sequence":"additional","affiliation":[{"name":"Hofstra University School of Medicine Hempstead NY"},{"name":"North Shore\u2013Long Island Jewish Health System Manhasset NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Sandor","sequence":"additional","affiliation":[{"name":"Toronto Western Research Institute University Health Network Toronto Ontario Canada"},{"name":"Youthdale Treatment Centers Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Barr","sequence":"additional","affiliation":[{"name":"Toronto Western Research Institute University Health Network Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Wolanczyk","sequence":"additional","affiliation":[{"name":"Department of Child Psychiatry Medical University of Warsaw Warsaw 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