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We wanted to determine whether tau reduction may also be of benefit in intractable genetic epilepsies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We studied a mouse model of Dravet syndrome, a severe childhood epilepsy caused by mutations in the human\n                      <jats:italic>SCN1A<\/jats:italic>\n                      gene encoding the voltage\u2010gated sodium channel subunit Na\n                      <jats:sub>v<\/jats:sub>\n                      1.1. We genetically deleted 1 or 2\n                      <jats:italic>Tau<\/jats:italic>\n                      alleles in mice carrying an Na\n                      <jats:sub>v<\/jats:sub>\n                      1.1 truncation mutation (R1407X) that causes Dravet syndrome in humans, and examined their survival, epileptic activity, related hippocampal alterations, and behavioral abnormalities using observation, electroencephalographic recordings, acute slice electrophysiology, immunohistochemistry, and behavioral assays.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Tau ablation prevented the high mortality of Dravet mice and reduced the frequency of spontaneous and febrile seizures. It reduced interictal epileptic spikes in vivo and drug\u2010induced epileptic activity in brain slices ex vivo. Tau ablation also prevented biochemical changes in the hippocampus indicative of epileptic activity and ameliorated abnormalities in learning and memory, nest building, and open field behaviors in Dravet mice. Deletion of only 1\n                      <jats:italic>Tau<\/jats:italic>\n                      allele was sufficient to suppress epileptic activity and improve survival and nesting performance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Tau reduction may be of therapeutic benefit in Dravet syndrome and other intractable genetic epilepsies. Ann Neurol 2014;76:443\u2013456<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.24230","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T21:07:14Z","timestamp":1405544834000},"page":"443-456","source":"Crossref","is-referenced-by-count":142,"title":["Tau reduction prevents disease in a mouse model of\n                    <scp>D<\/scp>\n                    ravet syndrome"],"prefix":"10.1002","volume":"76","author":[{"given":"Ania L.","family":"Gheyara","sequence":"first","affiliation":[{"name":"Gladstone Institute of Neurological Disease University of California San Francisco San Francisco CA"},{"name":"Departments of Pathology University of California San Francisco San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravikumar","family":"Ponnusamy","sequence":"additional","affiliation":[{"name":"Gladstone Institute of Neurological Disease University of California San Francisco San Francisco 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