{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:40:03Z","timestamp":1787618403317,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T00:00:00Z","timestamp":1407715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007386","name":"Fondazione Cassa di Risparmio di Modena","doi-asserted-by":"crossref","award":["A.010@FCRMO RINT@MELFONINFO"],"award-info":[{"award-number":["A.010@FCRMO RINT@MELFONINFO"]}],"id":[{"id":"10.13039\/100007386","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the functional and structural brain correlates of eyelid myoclonus and absence seizures triggered by eye closure (eye closure sensitivity [ECS]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen patients with eyelid myoclonus with absences (EMA, Jeavons syndrome), 14 patients with idiopathic generalized epilepsies (IGE) without ECS, and 16 healthy controls (HC) underwent an electroencephalography (EEG)\u2010correlated functional magnetic resonance imaging (fMRI) and voxel brain morphometry (VBM) protocol. The functional study consisted of 30\u2010second epochs of eyes\u2010open and eyes\u2010closed conditions. The following EEG events were marked and the relative fMRI maps obtained: (1) eye closure times, (2) spontaneous blinking, and (3) spontaneous and eye closure\u2013triggered spike and wave discharges (SWD; for EMA and IGE). Within\u2010group and between\u2010groups comparisons were performed for fMRI and VBM data as appropriate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In EMA compared to HC and IGE we found: (1) higher blood oxygenation level\u2013dependent (BOLD) signal related to the eye closure over the visual cortex, the posterior thalamus, and the network implicated in the motor control of eye closure, saccades, and eye pursuit movements; and (2) increments in the gray matter concentration at the visual cortex and thalamic pulvinar, whereas decrements were observed at the bilateral frontal eye field area. No BOLD differences were detected when comparing SWD in EMA and IGE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Results demonstrated altered anatomo\u2010functional properties of the visual system in EMA. These abnormalities involve a circuit encompassing the occipital cortex and the cortical\/subcortical systems physiologically involved in the motor control of eye closure and eye movements. Our work supports EMA as an epileptic condition with distinctive features and provides a contribution to its classification among epileptic syndromes. Ann Neurol 2014;76:412\u2013427<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.24236","type":"journal-article","created":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T09:32:31Z","timestamp":1406712751000},"page":"412-427","source":"Crossref","is-referenced-by-count":75,"title":["The visual system in eyelid myoclonia with absences"],"prefix":"10.1002","volume":"76","author":[{"given":"Anna Elisabetta","family":"Vaudano","sequence":"first","affiliation":[{"name":"Department of Biomedical, Metabolic, and Neural Science University of Modena and Reggio Emilia Nuovo Ospedale Civile S. Agostino Estense (NOCSAE) Hospital, AUSL Modena, NOCSE Hospital Modena"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ruggieri","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic, and Neural Science University of Modena and Reggio Emilia Nuovo Ospedale Civile S. Agostino Estense (NOCSAE) Hospital, AUSL Modena, NOCSE Hospital Modena"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Tondelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic, and Neural Science University of Modena and Reggio Emilia Nuovo Ospedale Civile S. Agostino Estense (NOCSAE) Hospital, AUSL Modena, NOCSE Hospital Modena"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Avanzini","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic, and Neural Science University of Modena and Reggio Emilia Nuovo Ospedale Civile S. Agostino Estense (NOCSAE) Hospital, AUSL Modena, NOCSE Hospital Modena"},{"name":"Department of Neuroscience University of Parma Parma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Benuzzi","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic, and Neural Science University of Modena and Reggio Emilia Nuovo Ospedale Civile S. Agostino Estense (NOCSAE) Hospital, AUSL Modena, NOCSE Hospital Modena"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Gessaroli","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic, and Neural Science University of Modena and Reggio Emilia Nuovo Ospedale Civile S. Agostino Estense (NOCSAE) Hospital, AUSL Modena, NOCSE Hospital Modena"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Cantalupo","sequence":"additional","affiliation":[{"name":"Department of Life and Reproduction Sciences University of Verona Verona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Mastrangelo","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit V. Buzzi Hospital Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aglaia","family":"Vignoli","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Epilepsy Center, San Paolo Hospital University of Milan Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Di","family":"Bonaventura","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences University of Rome \u201cLa Sapienza,\u201d Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paola","family":"Canevini","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Epilepsy Center, San Paolo Hospital University of Milan Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo Dalla","family":"Bernardina","sequence":"additional","affiliation":[{"name":"Department of Life and Reproduction Sciences University of Verona Verona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo Frigio","family":"Nichelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic, and Neural Science University of Modena and Reggio Emilia Nuovo Ospedale Civile S. Agostino Estense (NOCSAE) Hospital, AUSL Modena, NOCSE Hospital Modena"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Meletti","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic, and Neural Science University of Modena and Reggio Emilia Nuovo Ospedale Civile S. Agostino Estense (NOCSAE) Hospital, AUSL Modena, NOCSE Hospital Modena"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1528-1167.1966.tb06262.x","article-title":"Triggering mechanisms in epilepsy","volume":"7","author":"Gastaut H","year":"1966","journal-title":"The electroclinical point of view. Epilepsia"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2001.30600.x"},{"key":"e_1_2_9_4_1","first-page":"475","volume-title":"Reflex epilepsies and reflex seizures. Oxfordshire","author":"Panayiotopoulos CP","year":"2005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2001.10401.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02522.x"},{"key":"e_1_2_9_7_1","first-page":"77","volume-title":"Eyelid myoclonia with absences","author":"Duncan JS","year":"1996"},{"key":"e_1_2_9_8_1","first-page":"139","volume-title":"Reflex epilepsies and reflex seizures: advances in neurology","author":"Panayiotopoulos CP.","year":"1998"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2006.09.004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1977.tb08014.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.12.1312"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1996.tb00509.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0987-7053(02)00343-X"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-84882-128-6_159"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02114.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2009.04.004"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.028"},{"key":"e_1_2_9_18_1","first-page":"185","article-title":"Causality within the epileptic network: an EEG\u2010fMRI study validated by intracranial EEG","volume":"14","author":"Vaudano AE","year":"2013","journal-title":"Front Neurol"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.07.009"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910350312"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1140"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01724.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10548-013-0311-0"},{"key":"e_1_2_9_25_1","first-page":"356","article-title":"Stricninizzazione della sfera corticale visiva ed epilessia sperimentale da stimoli luminosi","volume":"27","author":"Clementi A.","year":"1929","journal-title":"Arch Fisiol"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03068.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05658.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03411.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2054"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3106"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20728"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.08.025"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00749"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200402000-00005"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.451009.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb00907.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.06.045"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.05.026"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm129"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.1.176"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl306"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.10.058"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.24236","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.24236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T09:37:38Z","timestamp":1696585058000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.24236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,11]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1002\/ana.24236"],"URL":"https:\/\/doi.org\/10.1002\/ana.24236","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,11]]}}}