{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:47:53Z","timestamp":1791528473062,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,9,19]],"date-time":"2014-09-19T00:00:00Z","timestamp":1411084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["13PRE16510003"],"award-info":[{"award-number":["13PRE16510003"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["ROI DC003681"],"award-info":[{"award-number":["ROI DC003681"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["ROI NS033576"],"award-info":[{"award-number":["ROI NS033576"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RO3 NS054958"],"award-info":[{"award-number":["RO3 NS054958"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Computation of a prearticulatory phonological representation (phonological access, or phonological retrieval) is an essential process in speech production whose neural localization is not clear. This study combined a specific behavioral measure of phonological access and multivariate voxel\u2010based lesion\u2010symptom mapping (VLSM) in a series of left hemisphere stroke patients to identify brain regions critical for this process.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Phonological access was assessed in 40 chronic ischemic stroke patients using a silent rhyming task to avoid confounds with motor planning and articulation deficits. Additional covariates were incorporated in the VLSM analysis to control for orthographic and working memory demands of the rhyming task, and for age, education, and total lesion volume. The resulting <jats:italic>t<\/jats:italic> statistic maps were thresholded at voxelwise <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 and cluster\u2010corrected at a familywise error of <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Phonological access impairment was correlated with damage to a focal region of cortex and white matter caudal to the posterior sylvian fissure, which included the posterior supramarginal gyrus and adjacent anterior angular gyrus, planum temporale, and posterior superior temporal gyrus. No correlation was observed with Broca's area, insula, or sensorimotor cortex. An additional VLSM showed no correlation between damage in this posterior perisylvian region and spoken word comprehension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>This is the first demonstration of a specific lesion correlate for phonological access impairment. Although this posterior perisylvian region overlaps with some versions of the classical Wernicke area, the present results demonstrate its involvement in prearticulatory phonological production rather than speech perception or lexical\u2013semantic processes. Ann Neurol 2014;76:738\u2013746<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.24266","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T09:03:46Z","timestamp":1409216626000},"page":"738-746","source":"Crossref","is-referenced-by-count":89,"title":["Cerebral localization of impaired phonological retrieval during rhyme judgment"],"prefix":"10.1002","volume":"76","author":[{"given":"Sara B.","family":"Pillay","sequence":"first","affiliation":[{"name":"Department of Neurology and Center for Imaging Research Medical College of Wisconsin Milwaukee WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin C.","family":"Stengel","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center for Imaging Research Medical College of Wisconsin Milwaukee WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Humphries","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center for Imaging Research Medical College of Wisconsin Milwaukee WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane S.","family":"Book","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center for Imaging Research Medical College of Wisconsin Milwaukee WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Binder","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center for Imaging Research Medical College of Wisconsin Milwaukee WI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmla.2000.2716"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cognition.2002.06.001"},{"key":"e_1_2_8_4_1","first-page":"91","volume-title":"Wernicke's works on aphasia: a sourcebook and review","author":"Wernicke C","year":"1874"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.100.4.589"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.108.1.204"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-0277(92)90038-J"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.114.2.273"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-0277(97)00027-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.104.4.801"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/02687040143000447"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2113"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01143-5"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp245"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2007.19.4.617"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.08.025"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.3.919"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/362342a0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1162\/089892901750363235"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1050"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/brln.1996.0015"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012619322-0\/50008-7"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws300"},{"key":"e_1_2_8_25_1","unstructured":"2001 Lippincott Williams & Wilkins Philadelphia PA H Goodglass E Kaplan B Barresi BDAE: the Boston Diagnostic Aphasia Examination"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr232"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.906424"},{"key":"e_1_2_8_28_1","volume-title":"Advanced Normalization Tools (ANTS)","author":"Avants BB","year":"2011"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617706061078"},{"key":"e_1_2_8_30_1","first-page":"231","volume-title":"Localization in neuropsychology","author":"Damasio H","year":"1983"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cognition.2013.05.007"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3158"},{"key":"e_1_2_8_33_1","first-page":"433","volume":"7","year":"1885","journal-title":"Lichtheim L. On aphasia. Brain"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/02643290342000582"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmla.1999.2637"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/01690965.2013.834370"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp055"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(00)01463-7"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cognition.2003.11.002"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl153"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3377-10.2010"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.06.054"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.24266","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.24266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T18:53:16Z","timestamp":1696618396000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.24266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,19]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1002\/ana.24266"],"URL":"https:\/\/doi.org\/10.1002\/ana.24266","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,19]]}}}