{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:32:34Z","timestamp":1785817954464,"version":"3.56.0"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T00:00:00Z","timestamp":1415664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000090","name":"Department of Defense Congressionally Directed Medical Research Programs","doi-asserted-by":"crossref","award":["W81XWH-09-1-0746"],"award-info":[{"award-number":["W81XWH-09-1-0746"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"NIH National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["NS079202"],"award-info":[{"award-number":["NS079202"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>Super\u2010refractory status epilepticus is a life\u2010threatening condition. Resistance to benzodiazepine and barbiturate treatment for this disorder is thought to be due to internalization of synaptic \u03b3\u2010aminobutyric acid (GABA)<jats:sub>A<\/jats:sub>receptors, and withdrawal of benzodiazepines and barbiturates during treatment often triggers seizure recurrence. The neurosteroid allopregnanolone acts as a positive allosteric modulator of synaptic and extrasynaptic GABA<jats:sub>A<\/jats:sub>receptors. Here we describe the use of allopregnanolone in 2 pediatric patients with super\u2010refractory status epilepticus. This treatment allowed the general anesthetic infusions to be weaned with resolution of status epilepticus. This is the first report of allopregnanolone use to treat status epilepticus in children. 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Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoAnne E.","family":"Natale","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California, Davis School of Medicine Sacramento CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Grimason","sequence":"additional","affiliation":[{"name":"Ruth D. and Ken M. Davee Pediatric Neurocritical Care Program, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Ruth D. and Ken M. Davee Pediatric Neurocritical Care Program, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Ruth D. and Ken M. Davee Pediatric Neurocritical Care Program, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California, Davis School of Medicine Sacramento CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Kanes","sequence":"additional","affiliation":[{"name":"Sage Therapeutics Cambridge MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Rogawski","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California, Davis School of Medicine Sacramento CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Wainwright","sequence":"additional","affiliation":[{"name":"Ruth D. and Ken M. Davee Pediatric Neurocritical Care Program, Ann and Robert H. 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