{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:32:12Z","timestamp":1791178332414,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,14]],"date-time":"2015-02-14T00:00:00Z","timestamp":1423872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Instituto Salud Carlos III","award":["PS09\/00259"],"award-info":[{"award-number":["PS09\/00259"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We set out to assess the dynamics of retinal injury after acute optic neuritis (ON) and their association with clinical visual outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010one consecutive patients with acute ON were prospectively analyzed over a 6\u2010month follow\u2010up period. Each month, we used optical coherence tomography (OCT) to assess the thickness of peripapillary retinal nerve fiber layer (pRNFL) and segmented macular layers, as well as high\u2010contrast visual acuity, low\u2010contrast visual acuity (LCVA), color visual acuity (CVA), and visual fields (VF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this prospective study, we found that 6 months after clinical onset, ON eyes suffered a reduction in pRNFL (\u221245.3 \u03bcm) and macular thickness (\u221217.3 \u03bcm). Macular atrophy was due to the decrease of macular RNFL thickness (\u22127.8 \u03bcm) and that of the ganglion cell layer and inner plexiform layer (GCIP, \u221211.3 \u03bcm), whereas the thickness of the outer retinal layers increased slightly. The macular RNFL and GCIP thickness decreased in parallel, yet it always occurred more rapidly and more severely for the GCIP. The change in the GCIP thickness in the first month predicted the visual impairment by month 6; a decrease\u2009\u2265\u2009of 4.5 \u03bcm predicted poor LCVA (sensitivity of 93% and specificity of 88%), and a decrease of\u2009\u2265\u20097 \u03bcm predicted poor VF and CVA (sensitivity of 78% and 100% and specificity of 63% and 66%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Retinal axonal and neuronal damage develops quickly after ON onset. Assessment of ganglion cell layer thickness by OCT after ON onset can be used as an imaging marker of persistent visual disability. Ann Neurol 2015;77:517\u2013528<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.24351","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T23:50:15Z","timestamp":1420501815000},"page":"517-528","source":"Crossref","is-referenced-by-count":161,"title":["Dynamics of retinal injury after acute optic neuritis"],"prefix":"10.1002","volume":"77","author":[{"given":"I\u00f1igo","family":"Gabilondo","sequence":"first","affiliation":[{"name":"Center of Neuroimmunology and Department of Neurology August Pi Sunyer Institute of Biomedical Research, Hospital Clinic of Barcelona, University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena H.","family":"Mart\u00ednez\u2010Lapiscina","sequence":"additional","affiliation":[{"name":"Center of Neuroimmunology and Department of Neurology August Pi Sunyer Institute of Biomedical Research, Hospital Clinic of Barcelona, University of Barcelona Barcelona 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