{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:49:59Z","timestamp":1788922199598,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T00:00:00Z","timestamp":1426204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003030","name":"AGAUR","doi-asserted-by":"crossref","award":["2009 SGR 1337"],"award-info":[{"award-number":["2009 SGR 1337"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fondo de Investigaciones Sanitarias (FIS) Instituto de Salud Carlos III","award":["12\/00840"],"award-info":[{"award-number":["12\/00840"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>Epidemiological studies have reported the co\u2010occurrence of Parkinson disease (PD) and melanoma. Common genetic variants in the <jats:italic>MC1R<\/jats:italic> (melanocortin 1 receptor) gene, which determines skin and hair color, are associated with melanoma. Here we investigated whether genetic variants in <jats:italic>MC1R<\/jats:italic> modulate the risk of PD by sequencing the entire gene in 870 PD patients and 736 controls ascertained from Spain. We found that the <jats:italic>MC1R<\/jats:italic> variant p.R160W (rs1805008) is marginally associated with PD (odds ratio\u2009=\u20092.10, gender\u2010 and age\u2010adjusted p\u2009=\u20090.009, Bonferroni\u2010corrected p\u2009=\u20090.063). Our results suggest that <jats:italic>MC1R<\/jats:italic> genetic variants modulate the risk of PD disease in the Spanish population. Ann Neurol 2015;77:889\u2013894<\/jats:p>","DOI":"10.1002\/ana.24373","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T06:31:05Z","timestamp":1422513065000},"page":"889-894","source":"Crossref","is-referenced-by-count":54,"title":["The <scp><i>MC1R<\/i><\/scp> melanoma risk variant p.<scp>R160W<\/scp> is associated with <scp>P<\/scp>arkinson disease"],"prefix":"10.1002","volume":"77","author":[{"given":"Gemma","family":"Tell\u2010Marti","sequence":"first","affiliation":[{"name":"Dermatology Department Melanoma Unit, Hospital Cl\u00ednic and August Pi i Sunyer Biomedical Research Institute (IDIBAPS)"},{"name":"Center for Biomedical Network Research on Rare Diseases (CIBERER), Carlos III Health Institute (ISCIII)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan Anton","family":"Puig\u2010Butille","sequence":"additional","affiliation":[{"name":"Center for Biomedical Network Research on Rare Diseases (CIBERER), Carlos III Health Institute (ISCIII)"},{"name":"Biochemical and Molecular Genetics Service, Hospital Cl\u00ednic and August Pi i Sunyer Biomedical Research Institute (IDIBAPS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Potrony","sequence":"additional","affiliation":[{"name":"Dermatology Department Melanoma Unit, Hospital Cl\u00ednic and August Pi i Sunyer Biomedical Research Institute (IDIBAPS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Badenas","sequence":"additional","affiliation":[{"name":"Center for Biomedical Network Research on Rare Diseases (CIBERER), Carlos III Health Institute (ISCIII)"},{"name":"Biochemical and Molecular Genetics Service, Hospital Cl\u00ednic and August Pi i Sunyer Biomedical Research Institute (IDIBAPS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Mil\u00e0","sequence":"additional","affiliation":[{"name":"Center for Biomedical Network Research on Rare Diseases (CIBERER), Carlos III Health Institute (ISCIII)"},{"name":"Biochemical and Molecular Genetics Service, Hospital Cl\u00ednic and August Pi i Sunyer Biomedical Research Institute (IDIBAPS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Malvehy","sequence":"additional","affiliation":[{"name":"Dermatology Department Melanoma Unit, Hospital Cl\u00ednic and August Pi i Sunyer Biomedical Research Institute (IDIBAPS)"},{"name":"Center for Biomedical Network Research on Rare Diseases (CIBERER), Carlos III Health Institute (ISCIII)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Mart\u00ed","sequence":"additional","affiliation":[{"name":"Laboratory of Neurodegenerative Disorders Department of Clinical and Experimental Neurology August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Hospital Cl\u00ednic of Barcelona, Center for Biomedical Network Research in Neurodegenerative Diseases (CIBERNED)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Ezquerra","sequence":"additional","affiliation":[{"name":"Laboratory of Neurodegenerative Disorders Department of Clinical and Experimental Neurology August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Hospital Cl\u00ednic of Barcelona, Center for Biomedical Network Research in Neurodegenerative Diseases (CIBERNED)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n","family":"Fern\u00e1ndez\u2010Santiago","sequence":"additional","affiliation":[{"name":"Laboratory of Neurodegenerative Disorders Department of Clinical and Experimental Neurology August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Hospital Cl\u00ednic of Barcelona, Center for Biomedical Network Research in Neurodegenerative Diseases (CIBERNED)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Puig","sequence":"additional","affiliation":[{"name":"Dermatology 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