{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:39:53Z","timestamp":1788309593077,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T00:00:00Z","timestamp":1431302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University of Wuerzburg"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>We retrospectively evaluated predictors of conversion to multiple sclerosis (MS) in 357 children with isolated optic neuritis (ON) as a first demyelinating event who had a median follow\u2010up of 4.0 years. Multiple Cox proportional\u2010hazards regressions revealed abnormal cranial magnet resonance imaging (cMRI; hazard ratio [HR]\u2009=\u20095.94, 95% confidence interval [CI]\u2009=\u20093.39\u201310.39, p\u2009&lt;\u20090.001), presence of cerebrospinal fluid immunoglobulin G oligoclonal bands (OCB; HR\u2009=\u20093.69, 95% CI\u2009=\u20092.32\u20135.86, p\u2009&lt;\u20090.001), and age (HR\u2009=\u20091.08 per year of age, 95% CI\u2009=\u20091.02\u20131.13, p\u2009=\u20090.003) as independent predictors of conversion, whereas sex and laterality (unilateral vs bilateral) had no influence. Combined cMRI and OCB positivity indicated a 26.84\u2010fold higher HR for developing MS compared to double negativity (95% CI\u2009=\u200912.26\u221258.74, p\u2009&lt;\u20090.001). Accordingly, cerebrospinal fluid analysis may supplement cMRI to determine the risk of MS in children with isolated ON. Ann Neurol 2015;77:1076\u20131082<\/jats:p>","DOI":"10.1002\/ana.24409","type":"journal-article","created":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T17:49:16Z","timestamp":1427392156000},"page":"1076-1082","source":"Crossref","is-referenced-by-count":68,"title":["Oligoclonal bands predict multiple sclerosis in children with optic neuritis"],"prefix":"10.1002","volume":"77","author":[{"given":"Nicole","family":"Heussinger","sequence":"first","affiliation":[{"name":"Children's Hospital Aschaffenburg Aschaffenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Kontopantelis","sequence":"additional","affiliation":[{"name":"Centre for Health Informatics, Institute of Population Health, University of Manchester Manchester United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janina","family":"Gburek\u2010Augustat","sequence":"additional","affiliation":[{"name":"Department of Neuropaediatrics Developmental 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