{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:55:19Z","timestamp":1789880119872,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council of Taiwan","doi-asserted-by":"crossref","award":["101-2314-B-002-163-MY3"],"award-info":[{"award-number":["101-2314-B-002-163-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council of Taiwan","doi-asserted-by":"crossref","award":["102-2321-B-002-082-"],"award-info":[{"award-number":["102-2321-B-002-082-"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council of Taiwan","doi-asserted-by":"crossref","award":["100-2320-B-002-083-MY3"],"award-info":[{"award-number":["100-2320-B-002-083-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council of Taiwan","doi-asserted-by":"crossref","award":["102-2321-B-002-061"],"award-info":[{"award-number":["102-2321-B-002-061"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Translational Medicine Project of National Taiwan University College of Medicine and National Taiwan University Hospital","award":["101C101-201"],"award-info":[{"award-number":["101C101-201"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Autonomic neuropathy is a major component of familial amyloid polyneuropathy (FAP) due to mutated transthyretin, with sudomotor failure as a common manifestation. This study aimed to investigate the pathology and clinical significance of sudomotor denervation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Skin biopsies were performed on the distal leg of FAP patients with a follow\u2010up duration of 3.8\u2009\u00b1\u20091.6 years. Sudomotor innervation was stained with 2 markers: protein gene product 9.5 (PGP 9.5), a general neuronal marker, and vasoactive intestinal peptide (VIP), a sudomotor nerve functional marker, followed by quantitation according to sweat gland innervation index (SGII) for PGP 9.5 (SGIIPGP 9.5) and VIP (SGIIVIP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 28 patients (25 men) with Ala97Ser transthyretin and late onset (59.9\u2009\u00b1\u20096.0 years) disabling neuropathy. Autonomic symptoms were present in 22 patients (78.6%) at the time of skin biopsy. The SGIIPGP 9.5 and SGIIVIP of FAP patients were significantly lower than those of age\u2010 and gender\u2010matched controls. The reduction of SGIIVIP was more severe than that of SGIIPGP 9.5 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). Patients with orthostatic hypotension or absent sympathetic skin response at palms were associated with lower SGIIPGP 9.5 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019 and 0.002, respectively). SGIIPGP 9.5 was negatively correlated with the disability grade at the time of skin biopsy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), and was positively correlated with the interval from the time of skin biopsy to the time of wheelchair usage (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>This study documented the pathological evidence of sudomotor denervation in FAP. SGIIPGP 9.5 was functionally correlated with autonomic symptoms, autonomic tests, ambulation status, and progression of disability. Ann Neurol 2015;78:272\u2103283<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.24438","type":"journal-article","created":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T03:30:21Z","timestamp":1431574221000},"page":"272-283","source":"Crossref","is-referenced-by-count":65,"title":["Sudomotor innervation in transthyretin amyloid neuropathy: Pathology and functional correlates"],"prefix":"10.1002","volume":"78","author":[{"given":"Chi\u2010Chao","family":"Chao","sequence":"first","affiliation":[{"name":"Department of Neurology National Taiwan University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cho\u2010Min","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology National Taiwan University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao\u2010Hua","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology National Taiwan University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai\u2010Ren","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology National Taiwan University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung\u2010Wei","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology National Taiwan University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi Chu\u2010Chiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology National Taiwan University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology National Taiwan University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whei\u2010Min","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology National Taiwan University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Mei","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology National Taiwan University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Jen","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology National Taiwan University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Tung","family":"Shun","sequence":"additional","affiliation":[{"name":"Department of Pathology National Taiwan University Hospital"},{"name":"Department of Forensic Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Tsang","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Neurology National Taiwan University Hospital"},{"name":"Department of Anatomy and Cell Biology National Taiwan University College of Medicine"},{"name":"Graduate Institute of Brain and Mind Sciences"},{"name":"Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70246-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.7.1057"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.7.1001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181ec7fda"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)74815-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318230b0f4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181a2e8b8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001488"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1607"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12276717"},{"key":"e_1_2_8_12_1","first-page":"933","article-title":"Liver transplantation in familial amyloidotic polyneuropathy","volume":"60","author":"Suhr OB","year":"1995","journal-title":"Follow\u2010up of the first 20 Swedish patients. 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