{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:00:09Z","timestamp":1770832809401,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T00:00:00Z","timestamp":1435622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004243","name":"Prinses Beatrix Spierfonds","doi-asserted-by":"publisher","award":["W.OR09-04"],"award-info":[{"award-number":["W.OR09-04"]}],"id":[{"id":"10.13039\/501100004243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Guillain\u2010Barr\u00e9 syndrome (GBS) is a postinfectious neuropathy most frequently caused by <jats:italic>Campylobacter jejuni<\/jats:italic>. Lipo\u2010oligosaccharides (LOS), expressed by <jats:italic>C. jejuni<\/jats:italic> induce antibodies that cross\u2010react with self\u2010glycolipids in peripheral nerves, causing neuropathy. Less than 1 in 1,000 persons infected with <jats:italic>C. jejuni<\/jats:italic> develop GBS, and the factors that determine GBS susceptibility are poorly understood. We hypothesized that these persons have a high intrinsic dendritic cell (DC) response to <jats:italic>C. jejuni<\/jats:italic> LOS through Toll\u2010like receptor 4 (TLR4) activation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Intrinsic DC responsiveness to <jats:italic>C. jejuni<\/jats:italic> LOS was investigated first in 20 healthy controls at three time points with a 3\u2010month interval, and second in patients, who previously developed GBS after a <jats:italic>C. jejuni<\/jats:italic> infection (n\u2009=\u200927) and controls (n\u2009=\u200926).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The DC response to <jats:italic>C. jejuni<\/jats:italic> LOS was highly variable between, but not within, healthy individuals, suggesting that intrinsic factors determine the magnitude of TLR4\u2010mediated innate response. High responsiveness to <jats:italic>C. jejuni<\/jats:italic> LOS by former GBS patients was evidenced by increased expression of CD38 and CD40. Frequency of CD38, CD40 and type I interferon high responders was significantly increased in the GBS group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>These results suggest that a strong response to TLR4 stimulation is a critical host condition for the development of GBS after an infection with <jats:italic>C. jejuni<\/jats:italic>. Ann Neurol 2015;78:343\u2013354<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.24442","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T02:45:02Z","timestamp":1432781102000},"page":"343-354","source":"Crossref","is-referenced-by-count":39,"title":["Innate <scp>I<\/scp>mmunity to <scp><i>C<\/i><\/scp><i>ampylobacter jejuni<\/i> in <scp>G<\/scp>uillain\u2010<scp>B<\/scp>arr\u00e9 <scp>S<\/scp>yndrome"],"prefix":"10.1002","volume":"78","author":[{"given":"Ruth","family":"Huizinga","sequence":"first","affiliation":[{"name":"Department of Immunology Erasmus MC, University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus MC, University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wouter","family":"van Rijs","sequence":"additional","affiliation":[{"name":"Department of Immunology Erasmus MC, University Medical Center Rotterdam The Netherlands"},{"name":"Department of Neurology Erasmus MC, University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne P.","family":"Tio\u2010Gillen","sequence":"additional","affiliation":[{"name":"Department of Immunology Erasmus MC, University Medical Center Rotterdam The Netherlands"},{"name":"Department of Neurology Erasmus MC, University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem Jan R.","family":"Fokkink","sequence":"additional","affiliation":[{"name":"Department of Immunology Erasmus MC, University Medical Center Rotterdam The Netherlands"},{"name":"Department of Neurology Erasmus MC, University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liesbeth E.","family":"Bakker\u2010Jonges","sequence":"additional","affiliation":[{"name":"Medical Laboratories Department of Immunology Reinier de Graaf Groep Delft The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Geleijns","sequence":"additional","affiliation":[{"name":"Department of Immunology Erasmus MC, University Medical Center Rotterdam The Netherlands"},{"name":"Department of Neurology Erasmus MC, University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janneke N.","family":"Samsom","sequence":"additional","affiliation":[{"name":"Division Gastroenterology and Nutrition Department of Pediatrics Erasmus MC, University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter A.","family":"van Doorn","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus MC, University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon D.","family":"Laman","sequence":"additional","affiliation":[{"name":"Department of Immunology Erasmus MC, University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart C.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Immunology Erasmus MC, University Medical Center Rotterdam The Netherlands"},{"name":"Department of Neurology Erasmus MC, University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","unstructured":"JacobsBC RothbarthPH van derMech\u00e9FG et al.The spectrum of antecedent infections in Guillain\u2010Barr\u00e9 syndrome: a case\u2010control study.Neurology1998;51:1110\u20131115.","DOI":"10.1212\/WNL.51.4.1110"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000160399.08456.7C"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/504294"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.6.610"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200415707"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/89831"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.9.5299-5303.2002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","unstructured":"AngCW vanDoornPA EndtzHP et al.A case of Guillain\u2010Barr\u00e9 syndrome following a family outbreak ofCampylobacter jejunienteritis.J Neuroimmunol2000;111:229\u2013233.","DOI":"10.1016\/S0165-5728(00)00369-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.156463"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2012.01667.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1183021"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903014"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.9.5008-5018.2002"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1246980"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1246949"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270707"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01765.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15324-X"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181e07d14"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92644-2"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318208824b"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00872-06"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.07.009"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301536"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0019-2805.2003.01803.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.468298"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2003.00179.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.04.077"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410330606"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.3.476"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2013.01.006"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268810002359"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.6.4211"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2012.03.006"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2011.7"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(93)90284-6"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.052282"},{"key":"e_1_2_8_39_1","first-page":"111","article-title":"Persistent abnormal TLR response and the effect of IVIg on TLR7 in Guillain\u2010Barr\u00e9 syndrome patients","volume":"18","author":"Suarez\u2010Calvet X","year":"2013","journal-title":"J Peripher Nerv Syst"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/414920a"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/09680519030090050601"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.12.003"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3158"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803944"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.cji.0000211345.11707.46"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.10.6208"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0759"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-1203"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/110.6.1617"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(96)00189-0"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.2119\/2006-00094.Molmed"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2913"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1101-1209"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00048-2"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.24442","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.24442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T11:53:35Z","timestamp":1696593215000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.24442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,30]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1002\/ana.24442"],"URL":"https:\/\/doi.org\/10.1002\/ana.24442","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,30]]}}}