{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:26:43Z","timestamp":1789727203312,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T00:00:00Z","timestamp":1435881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"NIMH","doi-asserted-by":"crossref","award":["MH02004"],"award-info":[{"award-number":["MH02004"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the association between odor identification deficits and future mortality in a multiethnic community cohort of older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were evaluated with the 40\u2010item University of Pennsylvania Smell Identification Test (UPSIT). Follow\u2010up occurred at 2\u2010year intervals with information on death obtained from informant interviews and the National Death Index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During follow\u2010up (mean\u2009=\u20094.1 years, standard deviation\u2009=\u20092.6), 349 of 1,169 (29.9%) participants died. Participants who died were more likely to be older (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), be male (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), have lower UPSIT scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and have a diagnosis of dementia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In a Cox model, the association between lower UPSIT score and mortality (hazard ratio [HR]\u2009=\u20091.07 per point interval, 95% confidence interval [CI]\u2009=\u20091.05\u20131.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) persisted after controlling for age, gender, education, ethnicity, language, modified Charlson medical comorbidity index, dementia, depression, alcohol abuse, head injury, smoking, body mass index, and vision and hearing impairment (HR\u2009=\u20091.05, 95% CI\u2009=\u20091.03\u20131.07,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Compared to the fourth quartile with the highest UPSIT scores, HRs for mortality for the first, second, and third quartiles of UPSIT scores were 3.81 (95% CI\u2009=\u20092.71\u20135.34), 1.75 (95% CI\u2009=\u20091.23\u20132.50), and 1.58 (95% CI\u2009=\u20091.09\u20132.30), respectively. Participant mortality rate was 45% in the lowest quartile of UPSIT scores (anosmia) and 18% in the highest quartile of UPSIT scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Impaired odor identification, particularly in the anosmic range, is associated with increased mortality in older adults even after controlling for dementia and medical comorbidity. Ann Neurol 2015;78:401\u2013411<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.24447","type":"journal-article","created":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T21:16:03Z","timestamp":1433193363000},"page":"401-411","source":"Crossref","is-referenced-by-count":136,"title":["Olfactory identification deficits and increased mortality in the community"],"prefix":"10.1002","volume":"78","author":[{"given":"Davangere P.","family":"Devanand","sequence":"first","affiliation":[{"name":"Division of Geriatric Psychiatry, Department of Psychiatry Columbia University New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seonjoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Biostatistics New York State Psychiatric Institute and Columbia University New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Manly","sequence":"additional","affiliation":[{"name":"Department of Neurology Gertrude H. 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Sergievsky Center, and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Masurkar","sequence":"additional","affiliation":[{"name":"Department of Neurology Gertrude H. Sergievsky Center, and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaakov","family":"Stern","sequence":"additional","affiliation":[{"name":"Department of Neurology Gertrude H. 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