{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:35:18Z","timestamp":1791578118505,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T00:00:00Z","timestamp":1450137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Detection of focal brain tau deposition during life could greatly facilitate accurate diagnosis of Alzheimer disease (AD), staging and monitoring of disease progression, and development of disease\u2010modifying therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We acquired tau positron emission tomography (PET) using\n                      <jats:sup>18<\/jats:sup>\n                      F T807 (AV1451), and amyloid\u2010\u03b2 PET using\n                      <jats:sup>11<\/jats:sup>\n                      C Pittsburgh compound B (PiB) in older clinically normal individuals, and symptomatic patients with mild cognitive impairment or mild AD dementia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found abnormally high cortical\n                      <jats:sup>18<\/jats:sup>\n                      F T807 binding in patients with mild cognitive impairment and AD dementia compared to clinically normal controls. Consistent with the neuropathology literature, the presence of elevated neocortical\n                      <jats:sup>18<\/jats:sup>\n                      F T807 binding particularly in the inferior temporal gyrus was associated with clinical impairment. The association of cognitive impairment was stronger with inferior temporal\n                      <jats:sup>18<\/jats:sup>\n                      F T807 than with mean cortical\n                      <jats:sup>11<\/jats:sup>\n                      C PIB. Regional\n                      <jats:sup>18<\/jats:sup>\n                      F T807 was correlated with mean cortical\n                      <jats:sup>11<\/jats:sup>\n                      C PiB among both impaired and control subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>\n                      These findings suggest that\n                      <jats:sup>18<\/jats:sup>\n                      F T807 PET could have value as a biomarker that reflects both the progression of AD tauopathy and the emergence of clinical impairment. ANN NEUROL 2016;79:110\u2013119\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.24546","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T12:38:35Z","timestamp":1445949515000},"page":"110-119","source":"Crossref","is-referenced-by-count":943,"title":["Tau positron emission tomographic imaging in aging and early\n                    <scp>A<\/scp>\n                    lzheimer disease"],"prefix":"10.1002","volume":"79","author":[{"given":"Keith A.","family":"Johnson","sequence":"first","affiliation":[{"name":"Division of Nuclear Medicine and Molecular Imaging Boston MA"},{"name":"Department of Neurology Boston MA"},{"name":"Department of Radiology Massachusetts General Hospital Boston MA"},{"name":"Center for Alzheimer Research and Treatment Department of Neurology Brigham and Women's Hospital Boston MA"},{"name":"Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Schultz","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine and Molecular Imaging Boston MA"},{"name":"Center for Alzheimer Research and Treatment Department of Neurology Brigham and Women's Hospital Boston MA"},{"name":"Athinoula A. Martinos Center for Biomedical Imaging Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Betensky","sequence":"additional","affiliation":[{"name":"Department of Medicine (Biostatistics Center) Massachusetts General Hospital Boston MA"},{"name":"Harvard School of Public Health Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Alex","family":"Becker","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine and Molecular Imaging Boston MA"},{"name":"Department of Radiology Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Sepulcre","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine and Molecular Imaging Boston MA"},{"name":"Department of Radiology Massachusetts General Hospital Boston MA"},{"name":"Harvard Medical School Boston MA"},{"name":"Athinoula A. 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