{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:29:48Z","timestamp":1790551788888,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T00:00:00Z","timestamp":1485216000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001157","name":"Harvard NeuroDiscovery Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001157","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Recent studies have shown that positron emission tomography (PET) tracer AV\u20101451 exhibits high binding affinity for paired helical filament (PHF)\u2010tau pathology in Alzheimer's brains. However, the ability of this ligand to bind to tau lesions in other tauopathies remains controversial. Our goal was to examine the correlation of <jats:italic>in vivo<\/jats:italic> and postmortem AV\u20101451 binding patterns in three autopsy\u2010confirmed non\u2010Alzheimer tauopathy cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We quantified <jats:italic>in vivo<\/jats:italic> retention of [F\u201018]\u2010AV\u20101451 and performed autoradiography, [H\u20103]\u2010AV\u20101451 binding assays, and quantitative tau measurements in postmortem brain samples from two progressive supranuclear palsy (PSP) cases and a <jats:italic>MAPT<\/jats:italic> P301L mutation carrier. They all underwent [F\u201018]\u2010AV\u20101451 PET imaging before death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The three subjects exhibited [F\u201018]\u2010AV\u20101451 <jats:italic>in vivo<\/jats:italic> retention predominantly in basal ganglia and midbrain. Neuropathological examination confirmed the PSP diagnosis in the first two subjects; the <jats:italic>MAPT<\/jats:italic> P301L mutation carrier had an atypical tauopathy characterized by grain\u2010like tau\u2010containing neurites in gray and white matter with heaviest burden in basal ganglia. In all three cases, autoradiography failed to show detectable [F\u201018]\u2010AV\u20101451 binding in multiple brain regions examined, with the exception of entorhinal cortex (reflecting incidental age\u2010related neurofibrillary tangles) and neuromelanin\u2010containing neurons in the substantia nigra (off\u2010target binding). The lack of a consistent significant correlation between <jats:italic>in vivo<\/jats:italic> [F\u201018]\u2010AV\u20101541 retention and postmortem <jats:italic>in vitro<\/jats:italic> binding and tau measures in these cases suggests that this ligand has low affinity for tau lesions primarily made of straight tau filaments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>AV\u20101451 may have limited utility for <jats:italic>in vivo<\/jats:italic> selective and reliable detection of tau aggregates in these non\u2010Alzheimer tauopathies. ANN NEUROL 2017;81:117\u2013128<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.24844","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T16:02:51Z","timestamp":1482249771000},"page":"117-128","source":"Crossref","is-referenced-by-count":183,"title":["Pathological correlations of [F\u201018]\u2010AV\u20101451 imaging in non\u2010alzheimer tauopathies"],"prefix":"10.1002","volume":"81","author":[{"given":"Marta","family":"Marqui\u00e9","sequence":"first","affiliation":[{"name":"MassGeneral Institute for NeuroDegenerative Disease Charlestown MA"},{"name":"Department of Neurology Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc D.","family":"Normandin","sequence":"additional","affiliation":[{"name":"Department of Radiology Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avery C.","family":"Meltzer","sequence":"additional","affiliation":[{"name":"MassGeneral Institute for NeuroDegenerative Disease Charlestown MA"},{"name":"Department of Neurology Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Siao Tick Chong","sequence":"additional","affiliation":[{"name":"MassGeneral Institute for NeuroDegenerative Disease Charlestown MA"},{"name":"Department of Neurology Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas V.","family":"Andrea","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Ant\u00f3n\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"MassGeneral Institute for NeuroDegenerative Disease Charlestown MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Klunk","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh School of Medicine Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chester A.","family":"Mathis","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pittsburgh School of Medicine Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos D.","family":"Ikonomovic","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pittsburgh School of Medicine Pittsburgh PA"},{"name":"Geriatric Research Education and Clinical Center, VA Pittsburgh Clinical System Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manik","family":"Debnath","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh School of Medicine Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Bien","sequence":"additional","affiliation":[{"name":"MassGeneral Institute for NeuroDegenerative Disease Charlestown MA"},{"name":"Department of Neurology Massachusetts General Hospital Boston MA"},{"name":"Harvard Neurodiscovery Center, Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R.","family":"Vanderburg","sequence":"additional","affiliation":[{"name":"MassGeneral Institute for NeuroDegenerative Disease Charlestown MA"},{"name":"Department of Neurology Massachusetts General Hospital Boston MA"},{"name":"Harvard Neurodiscovery Center, Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Costantino","sequence":"additional","affiliation":[{"name":"MassGeneral Institute for NeuroDegenerative Disease Charlestown MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Makaretz","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"DeVos","sequence":"additional","affiliation":[{"name":"MassGeneral Institute for NeuroDegenerative Disease Charlestown MA"},{"name":"Department of Neurology Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek H.","family":"Oakley","sequence":"additional","affiliation":[{"name":"MassGeneral Institute for NeuroDegenerative Disease Charlestown MA"},{"name":"C.S. 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