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Patterns of gray matter (GM) and white matter (WM) atrophy at presentation were assessed and tested as predictors of pathological diagnosis using support vector machine (SVM) algorithms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A clinical diagnosis of PPA was associated with frontotemporal lobar degeneration (FTLD) with transactive response DNA\u2010binding protein (TDP) inclusions in 40.5%, FTLD\u2010tau in 40.5%, and Alzheimer disease (AD) pathology in 19% of cases. Each variant was associated with 1 typical pathology; 24 of 29 (83%) svPPA showed FTLD\u2010TDP type C, 22 of 25 (88%) nfvPPA showed FTLD\u2010tau, and all 11 lvPPA had AD. Within FTLD\u2010tau, 4R\u2010tau pathology was commonly associated with nfvPPA, whereas Pick disease was observed in a minority of subjects across all variants except for lvPPA. Compared with pathologically typical cases, svPPA\u2010tau showed significant extrapyramidal signs, greater executive impairment, and severe striatal and frontal GM and WM atrophy. nfvPPA\u2010TDP patients lacked general motor symptoms or significant WM atrophy. Combining GM and WM volumes, SVM analysis showed 92.7% accuracy to distinguish FTLD\u2010tau and FTLD\u2010TDP pathologies across variants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Each PPA clinical variant is associated with a typical and most frequent cognitive, neuroimaging, and neuropathological profile. Specific clinical and early anatomical features may suggest rare and atypical pathological diagnosis in vivo. Ann Neurol 2017;81:430\u2013443<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.24885","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T04:17:06Z","timestamp":1485749826000},"page":"430-443","source":"Crossref","is-referenced-by-count":379,"title":["Typical and atypical pathology in primary progressive aphasia variants"],"prefix":"10.1002","volume":"81","author":[{"given":"Edoardo G.","family":"Spinelli","sequence":"first","affiliation":[{"name":"Memory and Aging Center University of California San Francisco San Francisco, CA"},{"name":"Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Mandelli","sequence":"additional","affiliation":[{"name":"Memory and Aging Center University of California San Francisco San Francisco, 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