{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:22:45Z","timestamp":1789672965905,"version":"4.0.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["UO1 NS074926"],"award-info":[{"award-number":["UO1 NS074926"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>Status epilepticus is common in neonates and infants, and is associated with neuronal injury and adverse developmental outcomes. \u03b3\u2010Aminobutyric acidergic (GABAergic) drugs, the standard treatment for neonatal seizures, can have excitatory effects in the neonatal brain, which may worsen the seizures and their effects. Using a recently developed model of status epilepticus in postnatal day 7 rat pups that results in widespread neuronal injury, we found that the GABA<jats:sub>A<\/jats:sub> agonists phenobarbital and midazolam significantly increased status epilepticus\u2013associated neuronal injury in various brain regions. Our results suggest that more research is needed into the possible deleterious effects of GABAergic drugs on neonatal seizures and on excitotoxic neuronal injury in the immature brain. Ann Neurol 2017;82:115\u2013120<\/jats:p>","DOI":"10.1002\/ana.24967","type":"journal-article","created":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T00:42:45Z","timestamp":1495845765000},"page":"115-120","source":"Crossref","is-referenced-by-count":60,"title":["Phenobarbital and midazolam increase neonatal seizure\u2010associated neuronal injury"],"prefix":"10.1002","volume":"82","author":[{"given":"Daniel","family":"Torolira","sequence":"first","affiliation":[{"name":"Epilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Suchomelova","sequence":"additional","affiliation":[{"name":"Epilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude G.","family":"Wasterlain","sequence":"additional","affiliation":[{"name":"Epilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System"},{"name":"Department of Neurology"},{"name":"Brain Research Institute, David Geffen School of Medicine at UCLA Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Niquet","sequence":"additional","affiliation":[{"name":"Epilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System"},{"name":"Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,7]]},"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.24967","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.24967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T20:04:13Z","timestamp":1696017853000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.24967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1002\/ana.24967"],"URL":"https:\/\/doi.org\/10.1002\/ana.24967","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7]]}}}