{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:44:49Z","timestamp":1790725489500,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>To characterize the mechanism of Zika virus (ZIKV)\u2010associated microcephaly, we performed immunolabeling on brain tissue from a 20\u2010week fetus with intrauterine ZIKV infection. Although ZIKV demonstrated a wide range of neuronal and non\u2010neuronal tropism, the infection rate was highest in intermediate progenitor cells and immature neurons. Apoptosis was observed in both infected and uninfected bystander cortical neurons, suggesting a role for paracrine factors in induction of neuronal apoptosis. Our results highlight differential neuronal susceptibility and neuronal apoptosis as potential mechanisms in the development of ZIKV\u2010associated microcephaly, and may provide insights into the design and best timing of future therapy. Ann Neurol 2017;82:121\u2013127<\/jats:p>","DOI":"10.1002\/ana.24968","type":"journal-article","created":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T00:42:44Z","timestamp":1495845764000},"page":"121-127","source":"Crossref","is-referenced-by-count":39,"title":["Differential neuronal susceptibility and apoptosis in congenital <scp>Z<\/scp>ika virus infection"],"prefix":"10.1002","volume":"82","author":[{"given":"Cheng\u2010Ying","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Pathology University of Maryland School of Medicine Baltimore MD"},{"name":"Division of Pathology, Children's National Health System Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather M.","family":"Ames","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins Medical Institutions Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Tipton","sequence":"additional","affiliation":[{"name":"Division of Pathology, Children's National Health System Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Vezina","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Imaging Children's National Health System Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy S.","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Neuroscience Research, Children's National Health System Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Scafidi","sequence":"additional","affiliation":[{"name":"Center for Neuroscience Research, Children's National Health System Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Torii","sequence":"additional","affiliation":[{"name":"Center for Neuroscience Research, Children's National Health System Washington DC"},{"name":"Department of Pediatrics School of Medicine and Health Sciences, George Washington University Washington DC"},{"name":"Pharmacology and Physiology, School of Medicine and Health Sciences George Washington University Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto J.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins Medical Institutions Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adre","family":"du Plessis","sequence":"additional","affiliation":[{"name":"Fetal Medicine Institute, Children's National Health System Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta L.","family":"DeBiasi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics School of Medicine and Health Sciences, George Washington University Washington DC"},{"name":"Fetal Medicine Institute, Children's National Health System Washington DC"},{"name":"Division of Pediatric Infectious Diseases, Children's National Health System Washington DC"},{"name":"Microbiology, Immunology, and Tropical Medicine, School of Medicine and Health Sciences George Washington University Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,25]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"75C","volume-title":"Zika: the origin and spread of a mosquito\u2010borne virus. Bull World Health Organ","author":"Kindhauser MK","year":"2016"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1602113"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1604338"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf6116"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.04.032"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.02.016"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18296"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.04.017"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.008"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1601824"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30883-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600651"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760160085"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2016-0343-OA"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr052"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/345375"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1604037"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/35097509"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/v4113020"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.4.2432-2439.2005"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/v5112856"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(94)90066-3"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2007.01.005"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i1901"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.24968","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.24968","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T20:03:48Z","timestamp":1696017828000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.24968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1002\/ana.24968"],"URL":"https:\/\/doi.org\/10.1002\/ana.24968","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7]]}}}