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CSF tau levels were compared between groups and correlated with digital histology measurement of postmortem tau pathology averaged from three cerebral regions (angular gyrus, mid\u2010frontal cortex, and anterior cingulate gyrus). Multivariate linear regression tested the association of ante mortem CSF tau levels with postmortem tau pathology adjusting for demographics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate regression found an independent association of ante mortem CSF phosphorylated tau levels with postmortem cerebral tau pathology in FTLD (Beta = 1.3; 95% confidence interval = 0.2\u20102.4; <jats:italic>p<\/jats:italic> &lt; 0.02). After excluding patients with coincident AD\u2010associated tau pathology accompanying sporadic FTLD, we found lower CSF phosphorylated tau levels in the TDP\u201043 group (median = 7.4pg\/ml; interquartile range [IQR] = 6.0, 12.3; n = 26) compared to the tauopathy group (median = 12.5pg\/ml; IQR = 10.7, 15.0; n = 23; Z = 2.6; <jats:italic>p<\/jats:italic> &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>CSF phosphorylated\u2010tau levels are positively associated with cerebral tau burden in FTLD. In vivo detection of AD copathology in sporadic FTLD patients may help stratify clinical cohorts with pure neuropathology in which low CSF phosphorylated\u2010tau levels may have diagnostic utility to distinguish TDP\u201043 proteinopathy from tauopathy. Autopsy\u2010confirmed samples are critical for FTLD biomarker development and validation. Ann Neurol 2017;82:247\u2013258<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.24996","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T15:56:38Z","timestamp":1500393398000},"page":"247-258","source":"Crossref","is-referenced-by-count":60,"title":["Ante mortem cerebrospinal fluid tau levels correlate with postmortem tau pathology in frontotemporal lobar degeneration"],"prefix":"10.1002","volume":"82","author":[{"given":"David J.","family":"Irwin","sequence":"first","affiliation":[{"name":"Center for Neurodegenerative Disease Research Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine Philadelphia PA"},{"name":"Frontotemporal Degeneration Center Department of Neurology, University of Pennsylvania Perelman School of Medicine Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Lle\u00f3","sequence":"additional","affiliation":[{"name":"Department of Neurology Institut d'Investigacions Biom\u00e8diques Sant Pau, Hospital de Sant Pau, Barcelona, Spain and Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas, CIBERNED Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon X.","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology University of Pennsylvania Perelman School of Medicine Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey T.","family":"McMillan","sequence":"additional","affiliation":[{"name":"Frontotemporal Degeneration Center Department of Neurology, University of Pennsylvania Perelman School of Medicine Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Wolk","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease Center Department of Neurology, University of Pennsylvania Perelman School of Medicine 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