{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:13:26Z","timestamp":1790140406236,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T00:00:00Z","timestamp":1502323200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100014803","name":"Turkish Neurological Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014803","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the clinical and distinctive imaging features of myelopathy associated with Beh\u00e7et's disease (BD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated the records of patients meeting the following criteria: (1) fulfillment of the International Study Group criteria for BD; (2) clinically suggestive of myelopathy; (3) simultaneous spinal cord and brain magnetic resonance images (MRIs) within 1 month of acute worsening of myelopathy; and (4) follow\u2010up duration\u2009\u2265\u20091 year after initial MRI evaluation. Patients not fulfilling all inclusion criteria and having MRIs with poor quality or missing sequences were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 11 patients (9 men, 2 women), we studied 14 MRIs during distinct myelopathy episodes and nine follow\u2010up MRIs. Two distinct MRI patterns of spinal cord involvement were described according to T2\u2010weighted (T2W) axial images: (1) \u201cBagel Sign\u201d pattern: a central lesion with hypointense core and hyperintense rim with or without contrast enhancement; and (2) \u201cMotor Neuron\u201d pattern: a symmetric involvement of the anterior horn cells. Bagel Sign was present in 13 of 14 myelopathy episodes whereas Motor Neuron pattern was observed in 1 of 14 MRIs. Of the 13 MRIs with Bagel Sign long myelopathy (n\u2009=\u20099), both long and short myelopathy (n\u2009=\u20092) and short myelopathy (n\u2009=\u20092) was observed. All patterns cleared with some residual lesions after steroid use and immunomodulation with associated clinical recovery in patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The signal characteristics of the Bagel Sign potentially represent venous engorgement and\/or acute blood products within the spinal cord. To our knowledge, Bagel Sign has not been observed in other forms of longitudinal myelopathy outside of BD, including neuromyelitis optica. 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