{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:17:02Z","timestamp":1785453422814,"version":"3.56.0"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010HD076436"],"award-info":[{"award-number":["R01\u2010HD076436"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08\u2010NS073796\u201005"],"award-info":[{"award-number":["K08\u2010NS073796\u201005"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We tested the hypothesis that somatosensory system injury would more strongly affect movement than motor system injury in children with unilateral cerebral palsy (USCP). This hypothesis was based on how somatosensory and corticospinal circuits adapt to injury during development; whereas the motor system can maintain connections to the impaired hand from the uninjured hemisphere, this does not occur in the somatosensory system. As a corollary, cortical injury strongly impairs sensory function, so we hypothesized that cortical lesions would impair hand function more than subcortical lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four children with unilateral cerebral palsy had physiological and anatomical measures of the motor and somatosensory systems and lesion classification. Motor physiology was performed with transcranial magnetic stimulation and somatosensory physiology with vibration\u2010evoked electroencephalographic potentials. Tractography of the corticospinal tract and the medial lemniscus was performed with diffusion tensor imaging, and lesions were classified by magnetic resonance imaging. Anatomical and physiological results were correlated with measures of hand function using 2 independent statistical methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Children with disruptions in the somatosensory connectivity and cortical lesions had the most severe upper extremity impairments, particularly somatosensory function. Motor system connectivity was significantly correlated with bimanual function, but not unimanual function or somatosensory function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Both sensory and motor connectivity impact hand function in children with USCP. Somatosensory connectivity could be an important target for recovery of hand function in children with USCP. Ann Neurol 2017;82:766\u2013780<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.25080","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T06:06:40Z","timestamp":1508134000000},"page":"766-780","source":"Crossref","is-referenced-by-count":60,"title":["Effect of sensory and motor connectivity on hand function in pediatric hemiplegia"],"prefix":"10.1002","volume":"82","author":[{"given":"Disha","family":"Gupta","sequence":"first","affiliation":[{"name":"Burke Medical Research Institute White Plains NY"},{"name":"Weill Cornell Medicine New York NY"},{"name":"Computational Science and Engineering Cornell University Ithaca NY"},{"name":"Helen Hayes Hospital West Haverstraw NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Barachant","sequence":"additional","affiliation":[{"name":"Burke Medical Research Institute White Plains NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew 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