{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:41:20Z","timestamp":1789875680699,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"InSightec (Haifa, Israel) the Focused Ultrasound Foundation"},{"name":"Binational Industrial Research and Development (BIRD) Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Magnetic resonance guided focused ultrasound (MRgFUS) has recently been investigated as a new treatment modality for essential tremor (ET), but the durability of the procedure has not yet been evaluated. This study reports results at a 2\u2010 year follow\u2010up after MRgFUS thalamotomy for ET.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 76 patients with moderate\u2010to\u2010severe ET, who had not responded to at least two trials of medical therapy, were enrolled in the original randomized study of unilateral thalamotomy and evaluated using the clinical rating scale for tremor. Sixty\u2010seven of the patients continued in the open\u2010label extension phase of the study with monitoring for 2 years. Nine patients were excluded by 2 years, for example, because of alternative therapy such as deep brain stimulation (n\u2009=\u20093) or inadequate thermal lesioning (n\u2009=\u20091). However, all patients in each follow\u2010up period were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean hand tremor score at baseline (19.8\u2009\u00b1\u20094.9; 76 patients) improved by 55% at 6 months (8.6\u2009\u00b1\u20094.5; 75 patients). The improvement in tremor score from baseline was durable at 1 year (53%; 8.9\u2009\u00b1\u20094.8; 70 patients) and at 2 years (56%; 8.8\u2009\u00b1\u20095.0; 67 patients). Similarly, the disability score at baseline (16.4\u2009\u00b1\u20094.5; 76 patients) improved by 64% at 6 months (5.4\u2009\u00b1\u20094.7; 75 patients). This improvement was also sustained at 1 year (5.4\u2009\u00b1\u20095.3; 70 patients) and at 2 years (6.5\u2009\u00b1\u20095.0; 67 patients). Paresthesias and gait disturbances were the most common adverse effects at 1 year\u2014each observed in 10 patients with an additional 5 patients experiencing neurological adverse effects. None of the adverse events worsened over the period of follow\u2010up, and 2 of these resolved. There were no new delayed complications at 2 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Tremor suppression after MRgFUS thalamotomy for ET is stably maintained at 2 years. Latent or delayed complications do not develop after treatment. Ann Neurol 2018;83:107\u2013114<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.25126","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T08:26:54Z","timestamp":1513672014000},"page":"107-114","source":"Crossref","is-referenced-by-count":161,"title":["A prospective trial of magnetic resonance\u2013guided focused ultrasound thalamotomy for essential tremor: Results at the 2\u2010year follow\u2010up"],"prefix":"10.1002","volume":"83","author":[{"given":"Jin Woo","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Lipsman","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Sunnybrook Health Sciences Centre Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Sunnybrook Health Sciences Centre Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pejman","family":"Ghanouni","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University School of Medicine Stanford CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaimie M.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Stanford University School of Medicine Stanford CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryder","family":"Gwinn","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Swedish Neuroscience Institute Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Witt","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Swedish Neuroscience Institute Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis S.","family":"Tierney","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Miami School of Medicine, Nicklaus Children's Hospital Miami FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Rees","family":"Cosgrove","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Brigham and Women's Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binit B.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Virginia Health Sciences Center Charlottesville VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tokyo Women's Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaomi","family":"Taira","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tokyo Women's Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres M.","family":"Lozano","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard M.","family":"Eisenberg","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Fishman","sequence":"additional","affiliation":[{"name":"Neurology, University of Maryland Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Jeffrey","family":"Elias","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Virginia Health Sciences Center Charlottesville VA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp010928"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870130105"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-999-0027-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.23.10.1105.32750"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(03)00259-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22059"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1986.65.3.0296"},{"key":"e_1_2_8_9_1","first-page":"727","article-title":"Surgery for tremor","volume":"5","author":"Israel Z","year":"2003","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_8_10_1","first-page":"755","article-title":"Treatment of tremor by stereotactic surgery","volume":"149","author":"Niclot P","year":"1993","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2008.01.004"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53497-2.00013-9"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2016.07.014"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3171\/2013.4.JNS13802"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3171\/JNS\/2008\/108\/01\/0111"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1178"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-307642"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600159"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21412"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70048-6"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.10.JNS16758"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10309"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-304943"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000098890"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3171\/2013.1.JNS121111"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.102.s_supplement.0234"},{"key":"e_1_2_8_27_1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3171\/jns.2002.97.supplement_5.0600","article-title":"Thalamic lesions produced by gamma thalamotomy for movement disorders","volume":"97","author":"Ohye C","year":"2002","journal-title":"J Neurosurg"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/2152-7806.91605"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000099662"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.09.012"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300962"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.25126","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.25126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T04:32:07Z","timestamp":1695529927000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.25126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/ana.25126"],"URL":"https:\/\/doi.org\/10.1002\/ana.25126","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732337126.793548330","asserted-by":"object"}]},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]}}}