{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T05:18:03Z","timestamp":1794115083351,"version":"4.8.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"French Ministry of Research and Higher Education"},{"name":"National Research Agency Project 2014-Immunity Sleep"},{"name":"Aviesan-ITMO 2014-BioNarcoImmunity"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the diagnostic value of extended sleep duration on a controlled 32\u2010hour bed rest protocol in idiopathic hypersomnia (IH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred sixteen patients with high suspicion of IH (37 clear\u2010cut IH according to multiple sleep latency test criteria and 79 probable IH), 32 with hypersomnolence associated with a comorbid disorder (non\u2010IH), and 21 controls underwent polysomnography, modified sleep latency tests, and a 32\u2010hour bed rest protocol. Receiver operating characteristic curves were used to find optimal total sleep time (TST) cutoff values on various periods that discriminate patients from controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TST was longer in patients with clear\u2010cut IH than other groups (probable IH, non\u2010IH, and controls) and in patients with probable IH than non\u2010IH and controls. The TST cutoff best discriminating clear\u2010cut IH and controls was 19 hours for the 32\u2010hour recording (sensitivity = 91.9%, specificity = 85.7%) and 12 hours (100%, 85.7%) for the first 24 hours. The 19\u2010hour cutoff displayed a specificity and sensitivity of 91.9% and 81.2% between IH and non\u2010IH patients. Patients with IH above the 19\u2010hour cutoff were overweight, had more sleep inertia, and had higher TST on all periods compared to patients below 19 hours, whereas no differences were found for the 12\u2010hour cutoff. An inverse correlation was found between the mean sleep latency and TST during 32\u2010hour recording in IH patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>In standardized and controlled stringent conditions, the optimal cutoff best discriminating patients from controls was 19 hours over 32 hours, allowing a clear\u2010cut phenotypical characterization of major interest for research purposes. Sleepier patients on the multiple sleep latency test were also the more severe in terms of extended sleep. 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