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Demographics, clinical phenotype, cognitive performance, and apolipoprotein e4 frequency were compared across clusters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cluster analysis identified a cluster with low entorhinal and cortical uptake (E<jats:sup>Lo<\/jats:sup>\/C<jats:sup>Lo<\/jats:sup>), one with low entorhinal but high cortical uptake (E<jats:sup>Lo<\/jats:sup>\/C<jats:sup>Hi<\/jats:sup>), and one with high cortical and entorhinal uptake (E<jats:sup>Hi<\/jats:sup>\/C<jats:sup>Hi<\/jats:sup>). Clinical phenotype differed across clusters, with typical AD most commonly observed in the E<jats:sup>Lo<\/jats:sup>\/C<jats:sup>Lo<\/jats:sup> and E<jats:sup>Hi<\/jats:sup>\/C<jats:sup>Hi<\/jats:sup> clusters, and atypical AD most commonly observed in the E<jats:sup>Lo<\/jats:sup>\/C<jats:sup>Hi<\/jats:sup> cluster. The E<jats:sup>Lo<\/jats:sup>\/C<jats:sup>Lo<\/jats:sup> cluster had an older age at PET and onset than the other clusters. Apolipoprotein e4 frequency was lower in the E<jats:sup>Lo<\/jats:sup>\/C<jats:sup>Hi<\/jats:sup> cluster. The E<jats:sup>Hi<\/jats:sup>\/C<jats:sup>Hi<\/jats:sup> cluster had the worst memory impairment, whereas the E<jats:sup>Lo<\/jats:sup>\/C<jats:sup>Hi<\/jats:sup> cluster had the worst impairment in nonmemory domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>This study demonstrates considerable variability in [<jats:sup>18<\/jats:sup>F]AV\u20101451 tau\u2010PET uptake in AD, but shows that a straightforward clustering based on entorhinal and cortical uptake maps well onto age and clinical presentation in AD. Ann Neurol 2018 Ann Neurol 2018;83:248\u2013257<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.25142","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T17:09:01Z","timestamp":1515690541000},"page":"248-257","source":"Crossref","is-referenced-by-count":96,"title":["[<sup>18<\/sup>F]AV\u20101451 clustering of entorhinal and cortical uptake in Alzheimer's disease"],"prefix":"10.1002","volume":"83","author":[{"given":"Jennifer L.","family":"Whitwell","sequence":"first","affiliation":[{"name":"Department of Radiology Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Graff\u2010Radford","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirubol","family":"Tosakulwong","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester 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