{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:27:16Z","timestamp":1788380836338,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004888","name":"Illinois Department of Public Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004888","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30 AG010161"],"award-info":[{"award-number":["P30 AG010161"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["RF1 AG015819"],"award-info":[{"award-number":["RF1 AG015819"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AG17917"],"award-info":[{"award-number":["R01 AG17917"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["RF1 AG22018"],"award-info":[{"award-number":["RF1 AG22018"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AG11101"],"award-info":[{"award-number":["R01 AG11101"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AG051635"],"award-info":[{"award-number":["R01 AG051635"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AG40039"],"award-info":[{"award-number":["R01 AG40039"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 NS084965"],"award-info":[{"award-number":["R01 NS084965"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine relationships of memory complaints to cognitive function and decline, incident dementia, and neurodegenerative and other neuropathologies, as well as the population\u2010attributable risk for dementia in older black and white persons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 4,015 community\u2010based persons (28% black; 74% women; mean baseline age\u2009=\u200978 years) were enrolled in 1 of 4 longitudinal cohort studies, and another 2,937 in a population\u2010based cohort. Memory scores, assessed using 2 questions (5\u2010point Likert scales) were categorized as complaints present or absent. Global cognition and 5 cognitive domains were derived from annual neuropsychological tests. Dementia was assessed from these tests and additional data. Neuropathologic data were available for 1,350 deceased subjects with brain autopsies. Regression and mixed effects models were used to examine relationships of memory complaints to cognition and neuropathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline memory complaints (n\u2009=\u20091,310; 33% of 4,015) were associated with lower cognition and faster decline in all domains (global score estimate\u2009=\u2009\u22120.032, standard error\u2009=\u20090.004,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), during a mean follow\u2010up of 6 (standard deviation\u2009=\u20092) years. Persons with memory complaints had higher dementia risk (hazard ratio\u2009=\u20091.64, 95% confidence interval [CI]\u2009=\u20091.42\u20131.89) and odds of pathologic Alzheimer disease (odds ratio [OR]\u2009=\u20091.96, 95% CI\u2009=\u20091.51\u20132.54), neocortical Lewy bodies (OR\u2009=\u20092.47, 95% CI\u2009=\u20091.54\u20133.96), and other neurodegenerative pathologies. Results for dementia risk were similar among blacks and whites. Among 2,937 older persons in a population\u2010based cohort with similar data, the population\u2010attributable risk for incident dementia due to memory complaints was 14.0% (95% CI\u2009=\u20092.6\u201323.0), and did not vary between the black and white groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Memory complaints are common in older black and white persons, and relate to cognitive decline, dementia risk, and neurodegenerative pathologies. Ann Neurol 2018;83:718\u2013729<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.25189","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T17:52:37Z","timestamp":1519235557000},"page":"718-729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Memory complaints, dementia, and neuropathology in older blacks and whites"],"prefix":"10.1002","volume":"83","author":[{"given":"Zoe","family":"Arvanitakis","sequence":"first","affiliation":[{"name":"Rush Alzheimer's Disease Center"},{"name":"Department of Neurological Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue E.","family":"Leurgans","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center"},{"name":"Department of Neurological Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra A.","family":"Fleischman","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center"},{"name":"Department of Neurological Sciences"},{"name":"Department of Behavioral Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center"},{"name":"Department of Neurological Sciences"},{"name":"Department of Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar B.","family":"Rajan","sequence":"additional","affiliation":[{"name":"Rush Institute for Healthy Aging"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy J.","family":"Pruzin","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center"},{"name":"Department of Neurological Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj C.","family":"Shah","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center"},{"name":"Department of Family Medicine Rush University Medical Center Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis A.","family":"Evans","sequence":"additional","affiliation":[{"name":"Rush Institute for Healthy Aging"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa L.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center"},{"name":"Department of Neurological Sciences"},{"name":"Department of Behavioral Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center"},{"name":"Department of Neurological Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Alzheimer's Disease International.World Alzheimer report 2015. The global impact of dementia: an analysis of prevalence incidence cost & trends. Available at:http:\/\/www.worldalzreport2015.org\/. Accessed March 15 2017."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12336"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317515592331"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldu029"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720512801322573"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720512801322663"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720512801322627"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001774"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.17.2.179"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617715001113"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000242734.16663.09"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.10.007"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1166(200011)15:11<983::AID-GPS238>3.0.CO;2-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4305"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.5.609"},{"key":"e_1_2_8_17_1","first-page":"347","article-title":"Self\u2010reported increased confusion or memory loss and associated functional difficulties among adults aged\u2009\u2265\u200960 years \u2014 21 states, 2011","volume":"62","author":"Adams ML","year":"2013","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002153"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12157"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-016-9332-2"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1993.tb06478.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12112"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12454"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12328"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.11.006"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988714532018"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2014.09.001"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617715000922"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.30"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/0361073X.2011.555640"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/089826439700900202"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afx077"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a8418b"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2015.01.008"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000144348.70643.F2"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000856"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988714532015"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.006616"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000250264.25017.21"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000715"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000159"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e3182420bdf"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.5888\/pcd13.150471"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.09.011"},{"key":"e_1_2_8_45_1","unstructured":"LinJS O'ConnorE RossomR et al.Screening for cognitive impairment in older adults: an evidence update for the U.S. Preventive Services Task Force. Evidence report No. 107. AHRQ publication No. 14\u201005198\u2010EF\u20101. Rockville MD: Agency for Healthcare Research and Quality 2013."},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000156"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4272"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2014.11.006"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350768"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.25189","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.25189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T01:51:27Z","timestamp":1694310687000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.25189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,30]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1002\/ana.25189"],"URL":"https:\/\/doi.org\/10.1002\/ana.25189","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,30]]},"assertion":[{"value":"2017-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}