{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T22:28:28Z","timestamp":1791757708768,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T00:00:00Z","timestamp":1524441600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"GENERATE network"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>\n                    We performed a genome\u2010wide association study in 1,194 controls and 150 patients with anti\u2010\n                    <jats:italic>N<\/jats:italic>\n                    \u2010methyl\u2010D\u2010aspartate receptor (anti\u2010NMDAR, n\u2009=\u200996) or anti\u2010leucine\u2010rich glioma\u2010inactivated1 (anti\u2010LGI1, n\u2009=\u200954) autoimmune encephalitis. Anti\u2010LGI1 encephalitis was highly associated with 27 single\u2010nucleotide polymorphisms (SNPs) in the HLA\u2010II region (leading SNP rs2858870\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20091.22\u2009\u00d7\u200910\n                    <jats:sup>\u221217<\/jats:sup>\n                    , OR\u2009=\u200913.66 [7.50\u201324.87]). Potential associations, below genome\u2010wide significance, were found with rs72961463 close to the doublecortin\u2010like kinase 2 gene (\n                    <jats:italic>DCLK2<\/jats:italic>\n                    ) and rs62110161 in a cluster of zinc\u2010finger genes. HLA allele imputation identified association of anti\u2010LGI1 encephalitis with HLA\u2010II haplotypes encompassing DRB1*07:01, DQA1*02:01 and DQB1*02:02 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20092.2\u2009\u00d7\u200910\n                    <jats:sup>\u221216<\/jats:sup>\n                    ) and anti\u2010NMDAR encephalitis with HLA\u2010I allele B*07:02 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.039). No shared genetic risk factors between encephalitides were identified. Ann Neurol 2018;83:863\u2013869\n                  <\/jats:p>","DOI":"10.1002\/ana.25216","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T21:42:11Z","timestamp":1521841331000},"page":"863-869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":152,"title":["Genetic predisposition in anti\u2010LGI1 and anti\u2010NMDA receptor encephalitis"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4881-7293","authenticated-orcid":false,"given":"Stefanie H.","family":"Mueller","sequence":"first","affiliation":[{"name":"Department of Neurology Christian\u2010Albrechts\u2010University Kiel  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"F\u00e4rber","sequence":"additional","affiliation":[{"name":"Neuroimmunology section, Institute of Clinical Chemistry University Hospital Schleswig\u2010Holstein Kiel\/L\u00fcbeck  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