{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:29:39Z","timestamp":1790648979712,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>The clinical phenotype of leucine\u2010rich glioma\u2010inactivated protein 1 (LGI1) and contactin\u2010associated proteinlike 2 (CASPR2) autoimmunity is well defined in adults. Data for children are limited (&lt;10 cases). Among 13,319 pediatric patients serologically tested for autoimmune neurological disorders (2010\u20132017), 264 were seropositive for voltage\u2010gated potassium channel\u2010complex\u2013IgG (radioimmunoprecipitation). Only 13 (4.9%) were positive by transfected cell\u2010binding assay for LGI1\u2010IgG (n\u2009=\u20097), CASPR2\u2010IgG (n\u2009=\u20093), or both (n\u2009=\u20093). This is significantly less than in adults. Encephalopathy, seizures, and peripheral nerve hyperexcitability were common, as was coexisting autoimmunity. No faciobrachial dystonic seizures or cancers were identified. Functional neurologic disorders were frequently the initial diagnosis, and immunotherapy appeared beneficial. 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