{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:36:00Z","timestamp":1792427760307,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS083373"],"award-info":[{"award-number":["R01 NS083373"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS037402"],"award-info":[{"award-number":["R01 NS037402"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08 NS070931"],"award-info":[{"award-number":["K08 NS070931"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 GM089778"],"award-info":[{"award-number":["R01 GM089778"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002736","name":"Citizens United for Research in Epilepsy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002736","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31401197"],"award-info":[{"award-number":["31401197"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20140318"],"award-info":[{"award-number":["BK20140318"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"Objective<\/jats:title>Several small case series identified KCTD7<\/jats:italic> mutations in patients with a rare autosomal recessive disorder designated progressive myoclonic epilepsy (EPM3) and neuronal ceroid lipofuscinosis (CLN14). Despite the name KCTD (potassium channel tetramerization domain), KCTD protein family members lack predicted channel domains. We sought to translate insight gained from yeast studies to uncover disease mechanisms associated with deficiencies in KCTD7 of unknown function.<\/jats:p><\/jats:sec>Methods<\/jats:title>Novel KCTD7<\/jats:italic> variants in new and published patients were assessed for disease causality using genetic analyses, cell\u2010based functional assays of patient fibroblasts and knockout yeast, and electron microscopy of patient samples.<\/jats:p><\/jats:sec>Results<\/jats:title>Patients with KCTD7<\/jats:italic> mutations can exhibit movement disorders or developmental regression before seizure onset, and are distinguished from similar disorders by an earlier age of onset. Although most published KCTD7<\/jats:italic> patient variants were excluded from a genome sequence database of normal human variations, most newly identified patient variants are present in this database, potentially challenging disease causality. However, genetic analysis and impaired biochemical interactions with cullin 3 support a causal role for patient KCTD7<\/jats:italic> variants, suggesting deleterious alleles of KCTD7<\/jats:italic> and other rare disease variants may be underestimated. Both patient\u2010derived fibroblasts and yeast lacking Whi2 with sequence similarity to KCTD7 have impaired autophagy consistent with brain pathology.<\/jats:p><\/jats:sec>Interpretation<\/jats:title>Biallelic KCTD7<\/jats:italic> mutations define a neurodegenerative disorder with lipofuscin and lipid droplet accumulation but without defining features of neuronal ceroid lipofuscinosis or lysosomal storage disorders. KCTD7<\/jats:italic> deficiency appears to cause an underlying autophagy\u2010lysosome defect conserved in yeast, thereby assigning a biological role for KCTD7. Ann Neurol 2018;84:774\u2013788<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.25351","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T11:16:29Z","timestamp":1538997389000},"page":"766-780","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["KCTD7<\/i> deficiency defines a distinct neurodegenerative disorder with a conserved autophagy\u2010lysosome defect"],"prefix":"10.1002","volume":"84","author":[{"given":"Kyle A.","family":"Metz","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology and Immunology Johns Hopkins University Bloomberg School of Public Health Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchen","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology Johns Hopkins University Bloomberg School of Public Health Baltimore MD"},{"name":"Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow University Suzhou Jiangsu Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Coppens","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology Johns Hopkins University Bloomberg School of Public Health Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather M.","family":"Lamb","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology Johns Hopkins University Bloomberg School of Public Health Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart E.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Histopathology Department Royal Hallamshire Hospital Sheffield United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5664-7987","authenticated-orcid":false,"given":"Jill A.","family":"Rosenfeld","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics Baylor College of Medicine Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghui","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow University Suzhou Jiangsu Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow University Suzhou Jiangsu Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry David Geffen School of Medicine at UCLA Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Meadow","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry David Geffen School of Medicine at UCLA Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim Sen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology Johns Hopkins University Bloomberg School of Public Health Baltimore MD"},{"name":"Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edda D.","family":"Haberlandt","sequence":"additional","affiliation":[{"name":"Clinical Department of Pediatrics I Innsbruck Medical University Innsbruck Austria"},{"name":"Department of Child and Youth Health Hospital of Dornbirn Dornbirn Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn W.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Histopathology Department Great Ormond Street Hospital for Children London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Leshinsky\u2010Silver","sequence":"additional","affiliation":[{"name":"Molecular Genetics Laboratory Wolfson Medical Center Holon Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics Baylor College of Medicine Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Markello","sequence":"additional","affiliation":[{"name":"NIH Undiagnosed Diseases Program, National Human Genome Research Institute National Institutes of Health Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marsha","family":"Pratt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Oklahoma College of Medicine Oklahoma City OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawal","family":"Makhseed","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jahra Hospital, Ministry of Health Al Jahra Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Garnica","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Arkansas for Medical Sciences and Arkansas Children's Hospital Little Rock AR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelle R.","family":"Danylchuk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Arkansas for Medical Sciences and Arkansas Children's Hospital Little Rock AR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Burrow","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Arkansas for Medical Sciences and Arkansas Children's Hospital Little Rock AR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parul","family":"Jayakar","sequence":"additional","affiliation":[{"name":"Division of Genetics and Metabolism Nicklaus Children's Hospital Miami FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianalee","family":"McKnight","sequence":"additional","affiliation":[{"name":"GeneDx Gaithersburg MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Agadi","sequence":"additional","affiliation":[{"name":"Department of Neurology Texas Children's Hospital Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatha","family":"Gbedawo","sequence":"additional","affiliation":[{"name":"Vital Kids Medicine Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Stanley","sequence":"additional","affiliation":[{"name":"Courtagen Life Sciences Woburn MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Alber","sequence":"additional","affiliation":[{"name":"Pediatric Neurology and Developmental Medicine University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Prehl","sequence":"additional","affiliation":[{"name":"Practice for Human Genetics, CeGaT T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Peariso","sequence":"additional","affiliation":[{"name":"Division of Neurology Cincinnati Children's Hospital Medical Center Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Tsui","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Sheffield Children's National Health Service Foundation Trust Sheffield United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh R.","family":"Mordekar","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Sheffield Children's National Health Service Foundation Trust Sheffield United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Parker","sequence":"additional","affiliation":[{"name":"Sheffield Clinical Genetics Service Sheffield Children's National Health Service Foundation Trust Sheffield United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Crooks","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Walton Centre National Health Service Foundation Trust Liverpool United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj B.","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Division of Genetics and Genomics, Manton Center for Orphan Disease Research Boston Children's Hospital, Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard T.","family":"Berry","sequence":"additional","affiliation":[{"name":"Division of Genetics and Genomics, Manton Center for Orphan Disease Research Boston Children's Hospital, Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Loddenkemper","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children's Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics Baylor College of Medicine Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo H. B.","family":"Maegawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Genetics and Metabolism University of Florida Gainesville FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6712-9595","authenticated-orcid":false,"given":"Abdel","family":"Aouacheria","sequence":"additional","affiliation":[{"name":"Montpellier Institute of Evolution Sciences University of Montpellier, CNRS, EPHE, IRD Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet G.","family":"Markle","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology Johns Hopkins University Bloomberg School of Public Health Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Wohlschlegel","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry David Geffen School of Medicine at UCLA Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5672-3409","authenticated-orcid":false,"given":"Adam L.","family":"Hartman","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4847-2045","authenticated-orcid":false,"given":"J. Marie","family":"Hardwick","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology Johns Hopkins University Bloomberg School of Public Health Baltimore MD"},{"name":"Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine Baltimore MD"},{"name":"Department of Neurology Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24470"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13595"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.04.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21121"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.09.026"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.117.014456"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2012-100859"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.2012.00710.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03516.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12730"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww244"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2054270415623145"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.05.023"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6545-z"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20170527"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-011-8194-0"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.05.011"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.04.027"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3232"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0061(19970630)13:8<707::AID-YEA130>3.0.CO;2-9"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.076406"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2013.05.024"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.117"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201696010"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E02-12-0830"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2006.07.001"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000077"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24929"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002807"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004152"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1518646112"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19057"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2016.08.031"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13961"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.21690"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2012.11.014"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/64.2.113"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn174"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e11-09-0785"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-08-0697"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.104"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.4600"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2007.11.015"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aah5642"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007592"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.3005"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.173"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.07.027"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.11.001"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318294b44c"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.25351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.25351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ana.25351","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.25351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T10:27:56Z","timestamp":1698143276000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.25351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1002\/ana.25351"],"URL":"https:\/\/doi.org\/10.1002\/ana.25351","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"2018-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}