{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:35:43Z","timestamp":1790962543825,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006556","name":"Centre Hospitalier Universitaire de Toulouse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether brain amyloid burden in elderly patients with narcolepsy type 1 (NT1) is lower than in controls, and to assess in patients with NT1 the relationships between amyloid burden, cerebral spinal fluid (CSF) markers of Alzheimer disease (AD), CSF orexin\u2010A, and cognitive profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cognitive and <jats:sup>18<\/jats:sup>F\u2010florbetapir positron emission tomography (PET) data were compared in patients with NT1 aged\u2009\u2265\u200965 years (n\u2009=\u200923) and in age\u2010 and sex\u2010matched controls free of clinical dementia selected from the Alzheimer's Disease Neuroimaging Initiative (ADNI; n\u2009=\u200969) and the Multi\u2010Domain Intervention Alzheimer's Prevention Trial (MAPT\u201018F AV45\u2010PET; n\u2009=\u200923) cohorts. The standardized uptake values (SUVs) of the cortical retention index for 6 regions of interest were computed and averaged to create a mean SUV ratio normalized to 3 subcortical reference regions (cerebellum, pons, and a composite region). A cortical\/cerebellum SUV ratio\u2009\u2265\u20091.17 defined positive PET amyloid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lower cortical amyloid burden was observed in the NT1 than in the ADNI and MAPT\u2010AV45 groups (mean cortical\/cerebellum SUV ratios\u2009=\u20090.95\u2009\u00b1\u20090.15, 1.11\u2009\u00b1\u20090.18 [<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001], and 1.14\u2009\u00b1\u20090.17 [<jats:italic>p<\/jats:italic>\u2009=\u20090.0005], respectively). Similar results were obtained with all subcortical reference regions and for all cortical regions of interest, except cingulum. Only 1 patient with NT1 (4.4%) had positive PET amyloid compared with 27.5% in the ADNI and 30.4% in the MAPT\u2010AV45 group. In the NT1 group, cortical or regional amyloid load was not associated with CSF orexin\u2010A, CSF AD biomarkers, or neuropsychological profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Lower brain amyloid burden, assessed by <jats:sup>18<\/jats:sup>F\u2010florbetapir PET, in patients with NT1 suggests delayed appearance of amyloid plaques. <jats:bold>ANN NEUROL 2019;85:74\u201383.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.25373","type":"journal-article","created":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T10:50:43Z","timestamp":1541155843000},"page":"74-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Reduced brain amyloid burden in elderly patients with narcolepsy type 1"],"prefix":"10.1002","volume":"85","author":[{"given":"Audrey","family":"Gabelle","sequence":"first","affiliation":[{"name":"Memory Research and Resources Center, Department of Neurology, Gui de Chauliac University Hospital Center"},{"name":"University of Montpellier"},{"name":"National Institute of Health and Medical Research U1061, Neuropsychiatry: Epidemiological and Clinical Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Jaussent","sequence":"additional","affiliation":[{"name":"University of Montpellier"},{"name":"National Institute of Health and Medical Research U1061, Neuropsychiatry: Epidemiological and Clinical Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fay\u00e7al Ben","family":"Bouall\u00e8gue","sequence":"additional","affiliation":[{"name":"University of Montpellier"},{"name":"Department of Nuclear Medicine Montpellier University Hospital"},{"name":"PhyMedExp, National Institute of Health and Medical Research, National Center for Scientific 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Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"B\u00e9ziat","sequence":"additional","affiliation":[{"name":"University of Montpellier"},{"name":"National Institute of Health and Medical Research U1061, Neuropsychiatry: Epidemiological and Clinical Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Mariano\u2010Goulart","sequence":"additional","affiliation":[{"name":"University of Montpellier"},{"name":"Department of Nuclear Medicine Montpellier University Hospital"},{"name":"PhyMedExp, National Institute of Health and Medical Research, National Center for Scientific Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Carlander","sequence":"additional","affiliation":[{"name":"Narcolepsy National Reference Center, Sleep Center, Department of Neurology Montpellier University Hospital Center  Montpellier 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