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An effective hand replacement can be achieved if the user, in addition to motor functions, is provided with the sensations that are naturally perceived while grasping and moving. Intraneural peripheral electrodes have shown promising results toward the restoration of the sense of touch. However, the long\u2010term usability and clinical relevance of intraneural sensory feedback have not yet been clearly demonstrated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To this aim, we performed a 6\u2010month clinical study with 3 transradial amputees who received implants of transverse intrafascicular multichannel electrodes (TIMEs) in their median and ulnar nerves. After calibration, electrical stimulation was delivered through the TIMEs connected to artificial sensors in the digits of a prosthesis to generate sensory feedback, which was then used by the subjects while performing different grasping tasks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All subjects, notwithstanding their important clinical differences, reported stimulation\u2010induced sensations from the phantom hand for the whole duration of the trial. They also successfully integrated the sensory feedback into their motor control strategies while performing experimental tests simulating tasks of real life (with and without the support of vision). Finally, they reported a decrement of their phantom limb pain and a general improvement in mood state.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>\n                      The promising results achieved with all subjects show the feasibility of the use of intraneural stimulation in clinical settings.\n                      <jats:bold>ANN NEUROL 2019;85:137\u2013154.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.25384","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T01:46:35Z","timestamp":1543196795000},"page":"137-154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":192,"title":["Six\u2010Month Assessment of a Hand Prosthesis with Intraneural Tactile Feedback"],"prefix":"10.1002","volume":"85","author":[{"given":"Francesco M.","family":"Petrini","sequence":"first","affiliation":[{"name":"Bertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, School of Engineering Swiss Federal Institute of Technology of Lausanne (EPFL)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Valle","sequence":"additional","affiliation":[{"name":"Bertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, School of Engineering Swiss Federal Institute of Technology of Lausanne (EPFL)  Lausanne Switzerland"},{"name":"Biorobotics Institute Sant'Anna School of Advanced Studies (SSSA)  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Strauss","sequence":"additional","affiliation":[{"name":"Bertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, School of Engineering Swiss Federal Institute of Technology of Lausanne (EPFL)  Lausanne Switzerland"},{"name":"Biorobotics Institute Sant'Anna School of Advanced Studies (SSSA)  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Granata","sequence":"additional","affiliation":[{"name":"Institute of Neurology Catholic University  Rome Italy"},{"name":"Department of Geriatrics, Neuroscience, and Orthopedics Policlinic A. 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