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Here, for the first time, we describe in detail the clinical and neuroimaging findings in 3 patients with early onset symptomatic amyloid\u2010\u03b2 cerebral amyloid angiopathy following childhood exposure to cadaveric dura (by neurosurgical grafting in 2 patients and tumor embolization in a third). Our observations provide further in vivo evidence that cerebral amyloid angiopathy might be caused by transmission of amyloid\u2010\u03b2 seeds (prions) present in cadaveric dura and have diagnostic relevance for younger patients presenting with suspected cerebral amyloid angiopathy. Ann Neurol 2019; 1\u20137\n                    <jats:bold>ANN NEUROL 2019;85:284\u2013290.<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1002\/ana.25407","type":"journal-article","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T17:39:16Z","timestamp":1546277956000},"page":"284-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Early onset cerebral amyloid angiopathy following childhood exposure to cadaveric dura"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0190-7782","authenticated-orcid":false,"given":"Gargi","family":"Banerjee","sequence":"first","affiliation":[{"name":"Stroke Research Centre, Department of Brain Repair and Rehabilitation University College London Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery  London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew E.","family":"Adams","sequence":"additional","affiliation":[{"name":"Lysholm Department of Neuroradiology National Hospital for Neurology and Neurosurgery  London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zane","family":"Jaunmuktane","sequence":"additional","affiliation":[{"name":"Department of Molecular Neuroscience University College London Queen Square Institute of Neurology  London"},{"name":"Division of Neuropathology National Hospital for Neurology and Neurosurgery  London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Alistair Lammie","sequence":"additional","affiliation":[{"name":"Department of Pathology Cardiff University  Cardiff"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Turner","sequence":"additional","affiliation":[{"name":"Barts and London School of Medicine and Dentistry Queen Mary University of London and Royal London Hospital  London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mushtaq","family":"Wani","sequence":"additional","affiliation":[{"name":"Morriston Hospital Abertawe Bro Morgannwg University Health Board  Swansea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inder M. S.","family":"Sawhney","sequence":"additional","affiliation":[{"name":"Morriston Hospital Abertawe Bro Morgannwg University Health Board  Swansea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Houlden","sequence":"additional","affiliation":[{"name":"Department of Molecular Neuroscience University College London Queen Square Institute of Neurology  London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Mead","sequence":"additional","affiliation":[{"name":"Medical Research Council Prion Unit at University College London University College London Institute of Prion Diseases  London"},{"name":"National Prion Clinic National Hospital for Neurology and Neurosurgery  London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Brandner","sequence":"additional","affiliation":[{"name":"Division of Neuropathology National Hospital for Neurology and Neurosurgery  London"},{"name":"Department of Neurodegenerative Disease University College London Queen Square Institute of Neurology  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Werring","sequence":"additional","affiliation":[{"name":"Stroke Research Centre, Department of Brain Repair and Rehabilitation University College London Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery  London"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15369"},{"key":"e_1_2_9_3_1","first-page":"146","article-title":"Amyloid\u2010beta pathology and cerebral amyloid angiopathy are frequent in iatrogenic Creutzfeldt\u2010Jakob disease after dural grafting","volume":"14287","author":"Frontzek K","year":"2016","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1703-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-017-0503-z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1565-x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1588-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12503"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1822-2"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1828-9"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.07.017"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493017741569"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003613"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23857"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.05.2351"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-317347"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19323"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.05.2353"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12218"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.5.1451"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.5.1470"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1194516"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20415"},{"key":"e_1_2_9_24_1","unstructured":"Public Health England. Creutzfeldt\u2010Jakob disease (CJD) biannual update (February 2018). Accessed date: January 11 2019. 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