{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:27:37Z","timestamp":1786976857503,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB TR128"],"award-info":[{"award-number":["SFB TR128"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>\n                    High levels of antibodies against glutamic acid decarboxylase (GAD) are observed in patients with different neurological disorders, but cells producing these autoantibodies are largely unexplored. We detect circulating GAD\u2010reactive B cells in peripheral blood that readily differentiate into antibody\u2010producing cells. These cells are highly elevated in most patients with GAD\u2010antibody\u2013associated disorders (n\u2009=\u200915) compared to controls (n\u2009=\u200919). They mainly produce GAD65 antibodies of the IgG1 and IgG4 subclasses and are as abundant as B cells reactive for common recall antigens. Bone marrow cells represent an additional source of GAD antibodies. The identification of GAD\u2010antibody\u2013producing cells has implications for the selection of cell\u2010specific biologics.\n                    <jats:bold>ANN NEUROL 2019;85:448\u2013454.<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1002\/ana.25414","type":"journal-article","created":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T00:03:37Z","timestamp":1547251417000},"page":"448-454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Abundant glutamic acid decarboxylase (GAD)\u2010reactive B cells in gad\u2010antibody\u2013associated neurological disorders"],"prefix":"10.1002","volume":"85","author":[{"given":"Franziska S.","family":"Thaler","sequence":"first","affiliation":[{"name":"Institute of Clinical Neuroimmunology University Hospital and Biomedical Center, Ludwig\u2010Maximilians University Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna 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