{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:28:14Z","timestamp":1786976894933,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T00:00:00Z","timestamp":1549238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the initial termination rate of status epilepticus (SE) in a large observational study and explore associated variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data of adults treated for SE were collected prospectively in centers in Germany, Austria, and Switzerland, during 4.5\u2009years. Incident episodes of 1,049 patients were analyzed using uni\u2010 and multivariate statistics to determine factors predicting cessation of SE within 1\u2009hour (for generalized convulsive SE [GCSE]) and 12\u2009hours (for non\u2010GCSE) of initiating treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median age at SE onset was 70\u2009years; most frequent etiologies were remote (32%) and acute (31%). GCSE was documented in 43%. Median latency between SE onset and first treatment was 30\u2009minutes in GCSE and 150\u2009minutes in non\u2010GCSE. The first intravenous compound was a benzodiazepine in 86% in GCSE and 73% in non\u2010GCSE. Bolus doses of the first treatment step were lower than recommended by current guidelines in 76% of GCSE patients and 78% of non\u2010GCSE patients. In 319 GCSE patients (70%), SE was ongoing 1\u2009hour after initiating treatment and in 342 non\u2010GCSE patients (58%) 12\u2009hours after initiating treatment. Multivariate Cox regression demonstrated that use of benzodiazepines as first treatment step and a higher cumulative dose of anticonvulsants within the first period of treatment were associated with shorter time to cessation of SE for both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>\n                      In clinical practice, treatment guidelines were not followed in a substantial proportion of patients. This underdosing correlated with lack of cessation of SE. Our data suggest that sufficiently dosed benzodiazepines should be used as a first treatment step.\n                      <jats:bold>ANN NEUROL 2019;85:421\u2013432.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.25416","type":"journal-article","created":{"date-parts":[[2019,1,20]],"date-time":"2019-01-20T06:25:51Z","timestamp":1547965551000},"page":"421-432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":130,"title":["Factors predicting cessation of status epilepticus in clinical practice: Data from a prospective observational registry (SENSE)"],"prefix":"10.1002","volume":"85","author":[{"given":"Christoph","family":"Kellinghaus","sequence":"first","affiliation":[{"name":"Department of Neurology Klinikum Osnabr\u00fcck Osnabr\u00fcck Germany"},{"name":"Epilepsy Center M\u00fcnster\u2010Osnabr\u00fcck Campus Osnabr\u00fcck Osnabr\u00fcck 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