{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:15:35Z","timestamp":1787724935893,"version":"build-2784847793"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:00:00Z","timestamp":1549324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>A novel diffusion\u2010weighted magnetic resonance imaging protocol sensitive to contraction of individual skeletal motor units was developed. We applied this technique to the lower limb muscles of 4 patients with confirmed amyotrophic lateral sclerosis (ALS) and 6 healthy controls. A 3\u2010minute scan revealed florid fasciculation in ALS patients, involving both superficial and deep muscles, and at a frequency higher than in healthy controls. This novel imaging technique reveals hitherto unobtainable information on human motor unit structure and function, which may allow earlier diagnosis and recruitment to clinical trials. <jats:bold>ANN NEUROL 2019;85:455\u2013459.<\/jats:bold><\/jats:p>","DOI":"10.1002\/ana.25422","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T13:13:31Z","timestamp":1548681211000},"page":"455-459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Functional magnetic resonance imaging of human motor unit fasciculation in amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"85","author":[{"given":"Roger G.","family":"Whittaker","sequence":"first","affiliation":[{"name":"Institute of Neuroscience Newcastle University  Newcastle upon Tyne United 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