{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:05:38Z","timestamp":1790129138539,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T00:00:00Z","timestamp":1552262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Federal Ministry of Labour, Social Affairs, Health and Consumer Protection"},{"name":"Medizinisch-Wissenschaftlichen Fonds des B\u00fcrgermeisters der Stadt Wien","award":["18097"],"award-info":[{"award-number":["18097"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Disease\u2010associated proteins are thought to propagate along neuronal processes in neurodegenerative diseases. To detect disease\u2010associated prion protein (PrP<jats:sup>Sc<\/jats:sup>) in the vagus nerve in different forms and molecular subtypes of Creutzfeldt\u2013Jakob disease (CJD), we applied 3 different anti\u2010PrP antibodies. We screened the vagus nerve in 162 sporadic and 30 genetic CJD cases. Four of 31 VV\u20102 type sporadic CJD and 7 of 30 genetic CJD cases showed vagal PrP<jats:sup>Sc<\/jats:sup> immunodeposits with distinct morphology. Thus, PrP<jats:sup>Sc<\/jats:sup> in CJD affects the vagus nerve analogously to \u03b1\u2010synuclein in Parkinson disease. The morphologically diverse deposition of PrP<jats:sup>Sc<\/jats:sup> in genetic and sporadic CJD argues against uniform mechanisms of propagation of PrP<jats:sup>Sc<\/jats:sup>. 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