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Outcome assessments included functional status at 90 days using the modified Rankin Scale (mRS), mortality, and delayed cerebral ischemia (DCI). The relationships between sST2 plasma level and outcome measures were assessed in both cross\u2010sectional and longitudinal analysis. Primary blood mononuclear cells from SAH patients and elective aneurysm controls were analyzed by multiparameter flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the discovery cohort, sST2 predicted 90\u2010day mRS 3\u20136 (C index = 0.724, <jats:italic>p<\/jats:italic> &lt;\u20090.001) and mortality in Kaplan\u2013Meier analysis (<jats:italic>p<\/jats:italic> &lt;\u20090.001). The association with functional status was independent of age, sex, World Federation of Neurosurgical Societies score, modified Fisher score, treatment modality, and cardiac comorbidities (adjusted odds ratio = 2.28, 95% confidence interval = 1.04\u20135.00, <jats:italic>p<\/jats:italic> =\u20090.039). Higher sST2 concentration was observed in those patients with DCI (90.8 vs 53.7ng\/ml, <jats:italic>p<\/jats:italic> =\u20090.003). These associations were confirmed in a replication cohort. In patients with high sST2, flow cytometry identified decreased expression of CD14 (4.27\u2009\u00d7\u200910<jats:sup>5<\/jats:sup> \u00b1\u20092,950 arbitrary unit (AU) vs 5.64\u2009\u00d7\u200910<jats:sup>5<\/jats:sup> \u00b1 1,290 AU, <jats:italic>p<\/jats:italic> &lt;\u20090.001), and increased expression of CD16 (39,960\u2009\u00b1\u2009272 AU vs 34,869\u2009\u00b1\u2009183 AU, <jats:italic>p<\/jats:italic> &lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Plasma sST2 predicts DCI, functional outcome, and mortality after SAH, independent of clinical and radiographic markers. Elevated sST2 is also associated with changes in CD14<jats:sup>+<\/jats:sup>CD16<jats:sup>+<\/jats:sup> monocytes. ANN NEUROL 2019;86:384\u2013394<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.25545","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T15:49:23Z","timestamp":1562773763000},"page":"384-394","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Soluble ST2 links inflammation to outcome after subarachnoid hemorrhage"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0878-8464","authenticated-orcid":false,"given":"Matthew B.","family":"Bevers","sequence":"first","affiliation":[{"name":"Divisions of Stroke, Cerebrovascular, and Critical Care Neurology Brigham and Women's Hospital  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Wolcott","sequence":"additional","affiliation":[{"name":"Division of Neurocritical Care, Center for Genomic Medicine Massachusetts General Hospital  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Bache","sequence":"additional","affiliation":[{"name":"Department of Neuroanesthesiology Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Hansen","sequence":"additional","affiliation":[{"name":"Division of Neurocritical Care, Center for Genomic Medicine Massachusetts General Hospital  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Sastre","sequence":"additional","affiliation":[{"name":"Division of Neurocritical Care, Center for Genomic Medicine Massachusetts General Hospital  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Mylvaganam","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Massachusetts General Hospital  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aman B.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Massachusetts General Hospital  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Neuroanesthesiology Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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