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In a secondary analysis of a large monocentric cohort of 446 TIA patients, we explored the frequency and determinants of diffusion\u2010weighted imaging (DWI) lesions on high\u2010resolution magnetic resonance imaging. Overall, 240 (54%) of all TIA patients presented with DWI lesions. These patients had higher National Institute of Health Stroke Scale and ABCD2 scores and presented more frequently with vessel occlusion and perfusion deficits, but had similar functional outcome at 3 months. Taken together, high\u2010resolution DWI provides evidence of ischemic brain injury in the majority of TIA patients. 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