{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:28:23Z","timestamp":1790008103979,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005969","name":"University of Bologna","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005969","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["RO1NS033310"],"award-info":[{"award-number":["RO1NS033310"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U54NS100064"],"award-info":[{"award-number":["U54NS100064"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to identify specific ictal hand postures (HPs) as localizing signs of the epileptogenic zone (EZ) in patients with frontal or temporal lobe epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we retrospectively analyzed ictal semiology of 489 temporal lobe or frontal lobe seizures recorded over a 6\u2010year period at the Seizure Disorder Center at University of California, Los Angeles in the USA (45 patients) or at the C. Munari Epilepsy Surgery Center at Niguarda Hospital in Milan, Italy (34 patients). Our criterion for EZ localization was at least 2\u2009years of seizure freedom after surgery. We analyzed presence and latency of ictal HP. We then examined whether specific initial HPs are predictive for EZ localization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that ictal HPs were present in 72.5% of patients with frontal and 54.5% of patients with temporal lobe seizures. We divided HPs into 6 classes depending on the reciprocal position of the fingers (\u201cfist,\u201d \u201ccup,\u201d \u201cpolitician's fist,\u201d \u201cpincer,\u201d \u201cextended hand,\u201d \u201cpointing\u201d). We found a striking correlation between EZ localization and ictal HP. In particular, fist and pointing HPs are strongly predictive of frontal lobe EZ; cup, politician's fist, and pincer are strongly predictive of temporal lobe EZ.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Our study offers simple ictal signs that appear to clarify differential diagnosis of temporal versus frontal lobe EZ localization. These results are meant to be used as a novel complementary tool during presurgical evaluation for epilepsy. At the same time, they give us important insight into the neurophysiology of hand movements. ANN NEUROL 2019;86:793\u2013800<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.25589","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T12:18:21Z","timestamp":1568031501000},"page":"793-800","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Hand posture as localizing sign in adult focal epileptic seizures"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8603-0061","authenticated-orcid":false,"given":"Isabella","family":"Ferando","sequence":"first","affiliation":[{"name":"Department of Neurology David Geffen School of Medicine at University of California, Los Angeles Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason R.","family":"Soss","sequence":"additional","affiliation":[{"name":"Department of Neurology David Geffen School of Medicine at University of California, Los Angeles Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Elder","sequence":"additional","affiliation":[{"name":"Department of Neurology David Geffen School of Medicine at University of California, Los Angeles Los Angeles CA"},{"name":"Seizure Disorder Center at University of California, Los Angeles Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Neurology David Geffen School of Medicine at University of California, Los Angeles Los Angeles CA"},{"name":"Seizure Disorder Center at University of California, Los Angeles Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Lo Russo","sequence":"additional","affiliation":[{"name":"C. 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