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Of these individuals, 12 patients with MS and 60 matching controls also underwent AV1451 tau PET. Cortical PiB and AV1451 standard uptake value ratios (SUVrs) from the entire cortex and previously determined Alzheimer disease (AD) signature regions in the same population were calculated for group comparisons and testing for associations with age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AD signature PiB SUVr (odds ratio [OR] [95% confidence interval (CI)] = 0.52 [0.27\u20130.98],<jats:italic>p<\/jats:italic>=\u20090.044), total cortical PiB SUVr (OR [95% CI] = 0.52 [0.28\u20130.99],<jats:italic>p<\/jats:italic>=\u20090.048), and the frequency of abnormal PiB SUVrs (OR [95% CI] = 0.10 [0.01\u20130.90],<jats:italic>p<\/jats:italic>=\u20090.040) were lower in MS than controls. Although AD\u2010signature and total cortical AV1451 SUVrs were not different between the groups, the frequency of abnormal AV1451 SUVrs was higher (OR [95% CI] = 10.65 [1.10\u2013103.35],<jats:italic>p<\/jats:italic>=\u20090.041) in MS than controls. The association of AD signature PiB SUVr with age was steeper in the controls compared to patients with MS (estimate [95% CI] = \u22120.14 [\u22120.023 to \u22120.006],<jats:italic>p<\/jats:italic>=\u20090.002). Similarly, the association of total cortical PiB SUVr with age was steeper in the controls compared to patients with MS (estimate [95% CI] = \u22120.13 [\u22120.021 to \u22120.005],<jats:italic>p<\/jats:italic>=\u20090.002). There was no difference in the association of AV1451 SUVr findings with age between the MS patients and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Although both \u03b2\u2010amyloid and tau are biomarkers of cognitive aging and AD, cortical \u03b2\u2010amyloid deposition was lower in MS than age\u2010matched controls, suggesting that some aspect of MS pathobiology retards the accumulation of \u03b2\u2010amyloid but not the accumulation of tau.<jats:bold>ANN NEUROL 2020;87:556\u2013567<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.25684","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T05:45:31Z","timestamp":1579758331000},"page":"556-567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Imaging Biomarkers of Alzheimer Disease in Multiple Sclerosis"],"prefix":"10.1002","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2270-9868","authenticated-orcid":false,"given":"Burcu","family":"Zeydan","sequence":"first","affiliation":[{"name":"Department of Radiology Mayo Clinic Rochester MN"},{"name":"Department of Neurology Mayo Clinic Rochester MN"},{"name":"Center for Multiple Sclerosis and Autoimmune Neurology Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val J.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross R.","family":"Reichard","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Przybelski","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research 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