{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:37:26Z","timestamp":1780677446853,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,22]],"date-time":"2020-02-22T00:00:00Z","timestamp":1582329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>Mutations in <jats:italic>GBA1,<\/jats:italic> the gene mutated in Gaucher disease, are a common genetic risk factor for Parkinson disease, although the penetrance is low. We performed [<jats:sup>18<\/jats:sup>F]\u2010fluorodopa positron emission tomography studies of 57 homozygous and heterozygous <jats:italic>GBA1<\/jats:italic> mutation carriers (15 with parkinsonism) and 98 controls looking for early indications of dopamine loss using voxelwise analyses to identify group differences in striatal [<jats:sup>18<\/jats:sup>F]\u2010fluorodopa uptake (K<jats:sub>i<\/jats:sub>). Forty\u2010eight subjects were followed longitudinally. Cross\u2010sectional and longitudinal comparisons of K<jats:sub>i<\/jats:sub> and K<jats:sub>i<\/jats:sub> change found significant effects of Parkinson disease. However, at baseline and over time, striatal [<jats:sup>18<\/jats:sup>F]\u2010fluorodopa uptake in mutation carriers without parkinsonism did not significantly differ from controls. <jats:bold>ANN NEUROL 2020;87:652\u2013657<\/jats:bold><\/jats:p>","DOI":"10.1002\/ana.25692","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T05:51:29Z","timestamp":1581054689000},"page":"652-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Longitudinal Positron Emission Tomography of Dopamine Synthesis in Subjects with <i>GBA1<\/i> Mutations"],"prefix":"10.1002","volume":"87","author":[{"given":"Grisel","family":"Lopez","sequence":"first","affiliation":[{"name":"Section on Molecular Neurogenetics, Medical Genetics Branch National Human Genome Research Institute, National Institutes of Health  Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel 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