{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:35:19Z","timestamp":1791578119546,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"am","delay-in-days":350,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K24 AG035007"],"award-info":[{"award-number":["K24 AG035007"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K99AG061238"],"award-info":[{"award-number":["K99AG061238"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P01 AG036694"],"award-info":[{"award-number":["P01 AG036694"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P50 AG005134"],"award-info":[{"award-number":["P50 AG005134"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41EB015896"],"award-info":[{"award-number":["P41EB015896"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201012\u20102\u20100012"],"award-info":[{"award-number":["W81XWH\u201012\u20102\u20100012"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The goal of this study was to examine sex differences in tau distribution across the brain of older adults, using positron emission tomography (PET), and investigate how these differences might associate with cognitive trajectories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Participants were 343 clinically normal individuals (women, 58%; 73.8 [8.5] years) and 55 individuals with mild cognitive impairment (MCI; women, 38%; 76.9 [7.3] years) from the Harvard Aging Brain Study and the Alzheimer's Disease Neuroimaging Initiative. We examined\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010Flortaucipir (FTP)\u2010positron emission tomography (PET) signal across 41 cortical and subcortical regions of interest (ROIs). Linear regression models estimated the effect of sex on FTP\u2010signal for each ROI after adjusting for age and cohort. We also examined interactions between sex*A\u03b2\u2010PET positive \/ negative (+ \/ \u2212) and sex*apolipoprotein \u03b54 (APOE\u03b54) status. Linear mixed models estimated the moderating effect of sex on the relationship between a composite of sex\u2010differentiated tau ROIs and cognitive decline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Women showed significantly higher FTP\u2010signals than men across multiple regions of the cortical mantle (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u20090.007). \u03b2\u2010amyloid (A\u03b2)\u2010moderated sex differences in tau signal were localized to medial and inferio\u2010lateral temporal regions (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u20090.007); A\u03b2 + women exhibited greater FTP\u2010signal than other groups. APOE\u03b54\u2010moderated sex differences in FTP\u2010signal were only found in the lateral occipital lobe. Women with higher FTP\u2010signals in composite ROI exhibited faster cognitive decline than men (\n                      <jats:italic>p<\/jats:italic>\n                      =\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Tau vulnerability in women is not just limited to the medial temporal lobe and significantly contributed to greater risk of faster cognitive decline. Interactive effects of sex and A\u03b2 were predominantly localized in the temporal lobe, however, sex differences in extra\u2010temporal tau highlights the possibility of accelerated tau proliferation in women with the onset of clinical symptomatology. ANN NEUROL 2020;88:921\u2013932<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.25878","type":"journal-article","created":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T03:54:45Z","timestamp":1597550085000},"page":"921-932","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":130,"title":["Sex Mediates Relationships Between Regional Tau Pathology and Cognitive Decline"],"prefix":"10.1002","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5356-5537","authenticated-orcid":false,"given":"Rachel F.","family":"Buckley","sequence":"first","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital and Harvard Medical School  Boston MA USA"},{"name":"Brigham and Women's Hospital Department of Neurology, Center for Alzheimer Research and Treatment  Boston MA USA"},{"name":"Melbourne School of Psychological Science University of Melbourne  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7620-3822","authenticated-orcid":false,"given":"Heidi I. L.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg Maastricht University  Maastricht The Netherlands"},{"name":"Division of Nuclear Medicine and Molecular Imaging, Department of Radiology Massachusetts General Hospital\/Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron P.","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Properzi","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca 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